Gene drive: evolved and synthetic

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Title: Gene drive: evolved and synthetic
Author(s): Burt, A
Crisanti, A
Item Type: Journal Article
Abstract: Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to-or indeed even if they detract from-organismal survival and reproduction. Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing endonuclease genes, B chromosomes, and transposable elements. The fact that gene drive can lead to the spread of fitness-reducing traits (including lethality and sterility) makes it an attractive process to consider exploiting to control disease vectors and other pests. There are a number of efforts to develop synthetic gene drive systems, particularly focused on the mosquito-borne diseases that continue to plague us.
Publication Date: 5-Feb-2018
Date of Acceptance: 1-Feb-2018
URI: http://hdl.handle.net/10044/1/57166
DOI: https://dx.doi.org/10.1021/acschembio.7b01031
ISSN: 1554-8929
Publisher: American Chemical Society
Start Page: 343
End Page: 346
Journal / Book Title: ACS Chemical Biology
Volume: 13
Issue: 2
Copyright Statement: This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Sponsor/Funder: The Royal Society
Grand Challenges in Global Health
Bill & Melinda Gates Foundation
Silicon Valley Community Foundation
Funder's Grant Number: WM110082
BURT12/VCTR
OPP1141988
N/A
Keywords: 03 Chemical Sciences
06 Biological Sciences
Organic Chemistry
Publication Status: Published online
Conference Place: United States
Open Access location: https://pubs.acs.org/doi/pdf/10.1021/acschembio.7b01031
Appears in Collections:Faculty of Natural Sciences



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