Tai-Chi and pulmonary rehabilitation compared for treatment-naïve patients with COPD; A Randomized Controlled Trial

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Title: Tai-Chi and pulmonary rehabilitation compared for treatment-naïve patients with COPD; A Randomized Controlled Trial
Author(s): Polkey, MI
Qiu, Z-H
Zhou, L
Zhu, M-D
Wu, Y-X
Chen, Y-Y
He, Y-S
Jiang, M
He, B-T
Mehta, B
Zhong, N-S
Luo, Y-M
Item Type: Journal Article
Abstract: Background In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St. George’s Respiratory Questionnaire [SGRQ] points) to PR. Methods A total of 120 patients (mean FEV1, 1.11 ± 0.42 L; 43.6% predicted) bronchodilator-naive patients were studied. Two weeks after starting indacaterol 150 μg once daily, they randomly received either standard PR thrice weekly or group Tai Chi five times weekly, for 12 weeks. The primary end point was change in SGRQ prior to and following the exercise intervention; measurements were also made 12 weeks after the end of the intervention. Results The between-group difference for SGRQ at the end of the exercise interventions was –0.48 (95% CI PR vs Tai Chi, –3.6 to 2.6; P = .76), excluding a difference exceeding the minimal clinically important difference. Twelve weeks later, the between-group difference for SGRQ was 4.5 (95% CI, 1.9 to 7.0; P < .001), favoring Tai Chi. Similar trends were observed for 6-min walk distance; no change in FEV1 was observed. Conclusions Tai Chi is equivalent to PR for improving SGRQ in COPD. Twelve weeks after exercise cessation, a clinically significant difference in SGRQ emerged favoring Tai Chi. Tai Chi is an appropriate substitute for PR.
Publication Date: 1-May-2018
Date of Acceptance: 30-Jan-2018
URI: http://hdl.handle.net/10044/1/57134
DOI: https://dx.doi.org/10.1016/j.chest.2018.01.053
ISSN: 0012-3692
Publisher: Elsevier
Start Page: 1116
End Page: 1124
Journal / Book Title: Chest
Volume: 153
Issue: 5
Copyright Statement: © 2018 The Authors. Published by Elsevier Inc under license from the American College of Chest Physicians. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords: COPD
Tai Chi
indacaterol
pulmonary rehabilitation
1103 Clinical Sciences
Respiratory System
Publication Status: Published
Online Publication Date: 2018-04-03
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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