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Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

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Title: Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
Authors: Buesen, R
Chorley, BN
Lima, BDS
Daston, G
Deferme, L
Ebbels, T
Gant, TW
Goetz, A
Greally, J
Gribaldo, L
Hackermueller, J
Hubesch, B
Jennen, D
Johnson, K
Kanno, J
Kauffmann, H-M
Laffont, M
McMullen, P
Meehan, R
Pemberton, M
Perdichizzi, S
Piersma, AH
Sauer, UG
Schmidt, K
Seitz, H
Sumida, K
Tollefsen, KE
Tong, W
Tralau, T
Van Ravenzwaay, B
Weber, RJM
Worth, A
Yauk, C
Poole, A
Item Type: Journal Article
Abstract: Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.
Issue Date: 25-Sep-2017
Date of Acceptance: 2-Sep-2017
URI: http://hdl.handle.net/10044/1/56973
DOI: https://dx.doi.org/10.1016/j.yrtph.2017.09.002
ISSN: 0273-2300
Publisher: Elsevier
Start Page: S3
End Page: S13
Journal / Book Title: Regulatory Toxicology and Pharmacology
Volume: 91
Copyright Statement: Crown Copyright © 2017 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Legal
Pharmacology & Pharmacy
Toxicology
Legal Medicine
Regulatory toxicology
Transcriptomics
Metabolomics
Good laboratory practice (GLP)
Weight-of-evidence (WoE)
Adverse outcome pathway (ADP)
Mode-of-action (MoA)
Gene expression
Differentially expressed genes
ADVERSE OUTCOME PATHWAYS
REGULATORY TOXICOLOGY
CONCEPTUAL-FRAMEWORK
KEY EVENTS
TOXICOGENOMICS
PERSPECTIVES
CONCORDANCE
CARCINOGENS
DEPARTURE
EXPOSURE
1115 Pharmacology And Pharmaceutical Sciences
Publication Status: Published
Appears in Collections:Division of Surgery
Faculty of Medicine



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