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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

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Title: Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
Authors: Spicer, C
Jumeaux, C
Gupta, B
Stevens, MM
Item Type: Journal Article
Abstract: Peptide– and protein–nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In this review, we focus on the key roles played by peptides and proteins in improving, controlling, and defining the performance of nanotechnologies. Within this framework, we provide a comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles. In doing so, we highlight the great advances made by the field, as well as the challenges still faced in achieving the clinical translation of peptide- and protein-functionalised nano-drug delivery vehicles, imaging species, and active therapeutics.
Issue Date: 26-Feb-2018
Date of Acceptance: 11-Feb-2018
URI: http://hdl.handle.net/10044/1/56930
DOI: https://dx.doi.org/10.1039/c7cs00877e
ISSN: 1460-4744
Publisher: Royal Society of Chemistry
Start Page: 3574
End Page: 3620
Journal / Book Title: Chemical Society Reviews
Volume: 47
Copyright Statement: © The Royal Society of Chemistry 2018
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Wellcome Trust
Commission of the European Communities
GlaxoSmithKline Services Unlimited
Funder's Grant Number: EP/K031953/1
EP/K020641/1
098411/Z/12/Z
ERC-2013-CoG-616417
Mark Buswell
Keywords: 03 Chemical Sciences
General Chemistry
Publication Status: Published
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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