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Gap junction plasticity as a mechanism to regulate network-wide oscillations

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Title: Gap junction plasticity as a mechanism to regulate network-wide oscillations
Authors: Pernelle, G
Nicola, W
Clopath, C
Item Type: Journal Article
Abstract: Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in cortex between GABAergic interneurons. Moreover, recent experiments indicate their strength can be modified in an activity-dependent manner, similar to chemical synapses. We hypothesized that activity-dependent gap junction plasticity acts as a mechanism to regulate oscillations in the cortex. We developed a computational model of gap junction plasticity in a recurrent cortical network based on recent experimental findings. We showed that gap junction plasticity can serve as a homeostatic mechanism for oscillations by maintaining a tight balance between two network states: asynchronous irregular activity and synchronized oscillations. This homeostatic mechanism allows for robust communication between neuronal assemblies through two different mechanisms: transient oscillations and frequency modulation. This implies a direct functional role for gap junction plasticity in information transmission in cortex.
Issue Date: 12-Mar-2018
Date of Acceptance: 6-Feb-2018
URI: http://hdl.handle.net/10044/1/56776
DOI: https://dx.doi.org/10.1371/journal.pcbi.1006025
ISSN: 1553-734X
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS Computational Biology
Volume: 14
Issue: 3
Copyright Statement: © 2018 Pernelle et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Mathematical & Computational Biology
Biochemistry & Molecular Biology
THALAMIC RETICULAR NUCLEUS
METABOTROPIC GLUTAMATE RECEPTORS
1ST-ORDER DIFFERENTIAL-EQUATIONS
ELECTRICALLY COUPLED NEURONS
GAMMA-BAND SYNCHRONIZATION
CENTRAL-NERVOUS-SYSTEM
FAST-SPIKING CELLS
INFERIOR OLIVE
VISUAL-CORTEX
IN-VIVO
q-bio.NC
06 Biological Sciences
08 Information And Computing Sciences
01 Mathematical Sciences
Bioinformatics
Publication Status: Published
Article Number: e1006025
Appears in Collections:Faculty of Engineering
Bioengineering



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