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Impact of traffic-related air pollution on acute changes in cardiac autonomic modulation during rest and physical activity: a cross-over study

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Title: Impact of traffic-related air pollution on acute changes in cardiac autonomic modulation during rest and physical activity: a cross-over study
Authors: Cole-Hunter, T
Weichenthal, S
Kubesch, N
Foraster, M
Carrasco-Turigas, G
Bouso, L
Martinez, D
Westerdahl, D
De Nazelle, A
Nieuwenhuijsen, M
Item Type: Journal Article
Abstract: People are often exposed to traffic-related air pollution (TRAP) during physical activity (PA), but it is not clear if PA modifies the impact of TRAP on cardiac autonomic modulation. We conducted a panel study among 28 healthy adults in Barcelona, Spain to examine how PA may modify the impact of TRAP on cardiac autonomic regulation. Participants completed four 2-h exposure scenarios that included either rest or intermittent exercise in high- and low-traffic environments. Time- and frequency-domain measures of heart rate variability (HRV) were monitored during each exposure period along with continuous measures of TRAP. Linear mixed-effects models were used to estimate the impact of TRAP on HRV as well as potential effect modification by PA. Exposure to TRAP was associated with consistent decreases in HRV; however, exposure–response relationships were not always linear over the broad range of exposures. For example, each 10 μg/m3 increase in black carbon was associated with a 23% (95% CI: −31, −13) decrease in high frequency power at the low-traffic site, whereas no association was observed at the high-traffic site. PA modified the impact of TRAP on HRV at the high-traffic site and tended to weaken inverse associations with measures reflecting parasympathetic modulation (P≤0.001). Evidence of effect modification at the low-traffic site was less consistent. The strength and direction of the relationship between TRAP and HRV may vary across exposure gradients. PA may modify the impact of TRAP on HRV, particularly at higher concentrations.
Issue Date: 21-Oct-2015
Date of Acceptance: 29-Aug-2015
URI: http://hdl.handle.net/10044/1/56555
DOI: https://dx.doi.org/10.1038/jes.2015.66
ISSN: 1559-0631
Publisher: Nature Publishing Group
Start Page: 133
End Page: 140
Journal / Book Title: Journal of Exposure Science and Environmental Epidemiology
Volume: 26
Issue: 2
Copyright Statement: Copyright © 2015, Springer Nature
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Public, Environmental & Occupational Health
Toxicology
Environmental Sciences & Ecology
heart rate variability
noise
particles
physical activity
traffic-related air pollution
HEART-RATE-VARIABILITY
PARTICULATE MATTER
EXPOSURE
EXERCISE
ULTRAFINE
ADULTS
PARTICLES
MORTALITY
BENEFITS
HUMANS
Adult
Air Pollutants
Air Pollution
Automobiles
Autonomic Nervous System
Cardiovascular Physiological Phenomena
Cross-Over Studies
Environmental Monitoring
Exercise
Female
Heart Rate
Humans
Linear Models
Male
Middle Aged
Particle Size
Particulate Matter
Rest
Soot
Spain
Vehicle Emissions
Young Adult
11 Medical And Health Sciences
03 Chemical Sciences
05 Environmental Sciences
Epidemiology
Publication Status: Published
Appears in Collections:Centre for Environmental Policy
Faculty of Natural Sciences



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