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Ultrasound imaging velocimetry with interleaved images for improved pulsatile arterial flow measurements: a new correction method, experimental and in vivo validation

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Title: Ultrasound imaging velocimetry with interleaved images for improved pulsatile arterial flow measurements: a new correction method, experimental and in vivo validation
Authors: Fraser, KH
Poelma, C
Zhou, B
Bazigou, E
Tang, M-X
Weinberg, PD
Item Type: Journal Article
Abstract: Blood velocity measurements are important in physiological science and clinical diagnosis. Doppler ultrasound is the most commonly used method but can only measure one velocity component. Ultrasound imaging velocimetry (UIV) is a promising technique capable of measuring two velocity components; however, there is a limit on the maximum velocity that can be measured with conventional hardware which results from the way images are acquired by sweeping the ultrasound beam across the field of view. Interleaved UIV is an extension of UIV in which two image frames are acquired concurrently, allowing the effective interframe separation time to be reduced and therefore increasing the maximum velocity that can be measured. The sweeping of the ultrasound beam across the image results in a systematic error which must be corrected: in this work, we derived and implemented a new velocity correction method which accounts for acceleration of the scatterers. We then, for the first time, assessed the performance of interleaved UIV for measuring pulsatile arterial velocities by measuring flows in phantoms and in vivo and comparing the results with spectral Doppler ultrasound and transit-time flow probe data. The velocity and flow rate in the phantom agreed within 5–10% of peak velocity, and 2–9% of peak flow, respectively, and in vivo the velocity difference was 9% of peak velocity. The maximum velocity measured was 1.8 m s−1, the highest velocity reported with UIV. This will allow flows in diseased arteries to be investigated and so has the potential to increase diagnostic accuracy and enable new vascular research.
Issue Date: 1-Feb-2017
Date of Acceptance: 3-Jan-2017
URI: http://hdl.handle.net/10044/1/56515
DOI: https://dx.doi.org/10.1098/rsif.2016.0761
ISSN: 1742-5662
Publisher: Royal Society, The
Journal / Book Title: Journal of the Royal Society Interface
Volume: 14
Issue: 127
Copyright Statement: © 2017 The Author(s) Published by the Royal Society. All rights reserved. Ultrasound imaging velocimetry with interleaved images for improved pulsatile arterial flow measurements: a new correction method, experimental and in vivo validation Katharine H. Fraser, Christian Poelma, Bin Zhou, Eleni Bazigou, Meng-Xing Tang, Peter D. Weinberg J. R. Soc. Interface 2017 14 20160761; DOI: 10.1098/rsif.2016.0761. Published 1 February 2017
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: RG/11/5/28743
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ultrasound
blood flow
atherosclerosis
haemodynamics
particle image velocimetry
echo-PIV
CAROTID-ARTERY
ECHO PIV
VELOCITY ESTIMATION
FLUID-MECHANICS
VECTOR
VITRO
QUANTIFICATION
STENOSIS
TRACKING
FIELDS
Animals
Male
Models, Cardiovascular
Pulsatile Flow
Rabbits
Ultrasonography, Doppler
MD Multidisciplinary
General Science & Technology
Publication Status: Published
Article Number: 20160761
Appears in Collections:Faculty of Engineering
Bioengineering



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