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Brief report: geographic variation in EGFR mutation frequency in lung adenocarcinoma may be explained by interethnic genetic variation

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Title: Brief report: geographic variation in EGFR mutation frequency in lung adenocarcinoma may be explained by interethnic genetic variation
Authors: Soraas, L
Stebbing, J
Item Type: Journal Article
Abstract: Our understanding of the etiology of EGFR mutant lung cancer remains incomplete. One persistent finding in the literature is the geographic variation in the frequency of EGFR mutations in lung adenocarcinoma. We investigated the association between two biomarkers of East Asian ancestry, the genetic polymorphisms EDAR V370A and ABCC11 G180A, and the frequency of EGFR mutations in lung adenocarcinoma patients in a range of countries. The Pearson's linear correlation between the frequency of EGFR mutations and the EDAR polymorphism was 0.92 (P < 2.2 x 10-10) and for the ABCC11 polymorphism it was 0.72 (P < 1.6 x 10-4). These results suggest that the variation in the measured frequency of EGFR mutations in lung adenocarcinoma can be explained, at least in part, by interethnic genetic variation. To improve our understanding of this disease, studies exploring the genetic polymorphism(s) that cause these interethnic differences, as well as the mechanisms of actions through which they work, are warranted.
Issue Date: 12-Dec-2017
Date of Acceptance: 17-Nov-2017
URI: http://hdl.handle.net/10044/1/56332
DOI: https://dx.doi.org/10.1016/j.jtho.2017.11.128
ISSN: 1556-0864
Publisher: Elsevier
Start Page: 454
End Page: 458
Journal / Book Title: Journal of Thoracic Oncology
Volume: 13
Issue: 3
Copyright Statement: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: National Institute for Health Research
Action Against Cancer
Funder's Grant Number: NIHR-RP-011-053
042017-01
Keywords: ABCC11 G180A polymorphism
EDAR V370A polymorphism
EGFR
Etiology
Interethnic genetic variation
Non–small cell lung cancer
biomarkers
etiology
interethnic genetic variation
non-small cell lung cancer
1103 Clinical Sciences
1102 Cardiovascular Medicine And Haematology
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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