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An epigenetic switch: from senescent melanocytes to malignant melanoma (and back)

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Title: An epigenetic switch: from senescent melanocytes to malignant melanoma (and back)
Authors: Wagner, V
Gil, J
Item Type: Journal Article
Abstract: Oncogene-induced senescence is an important barrier during melanomagenesis. In this issue of Cancer Cell, Yu et al. show how elevated expression of structurally unrelated H3K9 demethylases disables senescence and constitutes a liability that can be exploited to restore senescence in melanoma by pharmacological inhibition of these epigenetic regulators.
Issue Date: 12-Feb-2018
Date of Acceptance: 22-Jan-2018
URI: http://hdl.handle.net/10044/1/56298
DOI: https://dx.doi.org/10.1016/j.ccell.2018.01.013
ISSN: 1535-6108
Publisher: Elsevier (Cell Press)
Start Page: 162
End Page: 163
Journal / Book Title: Cancer Cell
Volume: 33
Issue: 2
Copyright Statement: © 2018 Elsevier Inc. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
2019-02-12
Keywords: 1112 Oncology And Carcinogenesis
1109 Neurosciences
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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