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The benefit of tumor molecular profiling on predicting treatments for colorectal adenocarcinomas

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Title: The benefit of tumor molecular profiling on predicting treatments for colorectal adenocarcinomas
Authors: Carter, P
Alifrangis, CC
Chandrasinghe, P
Cereser, B
Del Bel Belluz, L
Leo, CA
Moderau, N
Tabassum, N
Warusavitarne, J
Krell, J
Stebbing, J
Item Type: Journal Article
Abstract: We evaluated the benefit of tailoring treatments for a colorectal adenocarcinoma cancer cohort according to tumor molecular profiles, by analyzing data collected on patient responses to treatments that were guided by a tumor profiling technology from Caris Life Sciences. DNA sequencing and immunohistochemistry were the main tests that predictions were based upon, but also fragment analysis, and in situ hybridization. The status of the IHC biomarker for the thymidylate synthase receptor was a good indicator for future survival. Data collected for the clinical treatments of 95 colorectal adenocarcinoma patients was retrospectively divided into two groups: the first group was given drugs that always matched recommended treatments as suggested by the tumor molecular profiling service; the second group received at least one drug after profiling that was predicted to lack benefit. In the matched treatment group, 19% of patients were deceased at the end of monitoring compared to 49% in the unmatched group, indicating a benefit in mortality by tumor molecular profiling colorectal adenocarcinoma patients.
Issue Date: 16-Jan-2018
Date of Acceptance: 15-Nov-2017
URI: http://hdl.handle.net/10044/1/56272
DOI: https://dx.doi.org/10.18632/oncotarget.24257
ISSN: 1949-2553
Publisher: Impact Journals
Start Page: 11371
End Page: 11376
Journal / Book Title: Oncotarget
Volume: 9
Copyright Statement: © Carter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Action Against Cancer
Funder's Grant Number: 042016-06
Keywords: cancer treatment
colorectal adenocarcinoma
tumor profiling
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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