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Does molecular profiling of tumors using the Caris molecular intelligence platform improve outcomes for cancer patients?

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Title: Does molecular profiling of tumors using the Caris molecular intelligence platform improve outcomes for cancer patients?
Authors: Carter, P
Alifrangis, CC
Cereser, B
Chandrasinghe, P
Del Bel Belluz, L
Herzog, T
Levitan, J
Moderau, N
Schwartzberg, L
Tabassum, N
Wen, J
Krell, J
Stebbing, J
Item Type: Journal Article
Abstract: We evaluated the effect of tailoring treatments based on predictions informed by tumor molecular profiles across a range of cancers, using data from Caris Life Sciences. These included breast carcinoma, colorectal adenocarcinoma, female genital tract malignancy, lung non-small cell lung cancer, neuroendocrine tumors, ovarian surface epithelial carcinomas, and urinary tract cancers. Molecular profiles using mostly immunohistochemistry (IHC) and DNA sequencing for tumors from 841 patients had been previously used to recommend treatments; some physicians followed the suggestions completely while some did not. This information was assessed to find out if the outcome was better for the patients where their received drugs matched recommendations. The IHC biomarker for the progesterone receptor and for the androgen receptor were found to be most prognostic for survival overall. The IHC biomarkers for P-glycoprotein (PGP), tyrosine-protein kinase Met (cMET) and the DNA excision repair protein ERCC1 were also shown to be significant predictors of outcome. Patients whose treatments matched those predicted to be of benefit survived for an average of 512 days, compared to 468 days for those that did not (P = 0.0684). In the matched treatment group, 34% of patients were deceased at the completion of monitoring, whereas this was 47% in the unmatched group (P = 0.0001).
Issue Date: 16-Jan-2018
Date of Acceptance: 15-Nov-2017
URI: http://hdl.handle.net/10044/1/56271
DOI: https://dx.doi.org/10.18632/oncotarget.24258
ISSN: 1949-2553
Publisher: Impact Journals
Start Page: 9456
End Page: 9467
Journal / Book Title: Oncotarget
Volume: 9
Copyright Statement: © Carter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Action Against Cancer
Action Against Cancer
Funder's Grant Number: 042016-05
082017-03
Keywords: tumor molecular profiling
cancer treatment
Publication Status: Published online
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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