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malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication

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Title: malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication
Authors: Kaslow, DC
Okumu, F
Wells, TNC
Rabinovich, R
Bassat, Q
Birkett, A
Bompart, F
Burt, A
Chaccour, C
Chitnis, C
Culpepper, J
Domingo, G
Duffy, P
Ghani, A
Greenwood, B
Hall, BF
Hamon, N
Jacobs-Lorena, M
James, S
Koram, KA
Kremsner, P
Kumar, A
Leroy, D
Leroy, O
Lindsay, S
Majambere, S
Mbogo, C
McCarthy, J
Qi, G
Rasgon, J
Richardson, J
Richie, T
Sauerwein, R
Slutsker, L
Vekemans, J
Item Type: Journal Article
Abstract: Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination.
Issue Date: 30-Nov-2017
Date of Acceptance: 1-Nov-2017
URI: http://hdl.handle.net/10044/1/56048
DOI: https://dx.doi.org/10.1371/journal.pmed.1002455
ISSN: 1549-1277
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS Medicine
Volume: 14
Issue: 11
Copyright Statement: © 2017 The malERA Consultative Panel on Tools for Malaria Elimination. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Bill & Melinda Gates Foundation
Medical Research Council (MRC)
Funder's Grant Number: OPP1068440
MR/K010174/1B
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
PLASMODIUM-FALCIPARUM MALARIA
BLOOD-STAGE MALARIA
TRANSMISSION-BLOCKING ACTIVITY
RESISTANT ANOPHELES-GAMBIAE
NUCLEIC-ACID AMPLIFICATION
PYRIPROXYFEN MIXTURE NET
HIGH-THROUGHPUT ASSAY
GENE DRIVE SYSTEM
VIVAX INFECTION
DOUBLE-BLIND
11 Medical And Health Sciences
Publication Status: Published
Open Access location: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002455
Article Number: e1002455
Appears in Collections:Epidemiology, Public Health and Primary Care



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