The PPAR beta/delta Agonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension

Title: The PPAR beta/delta Agonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension
Authors: Harrington, LS
Moreno, L
Reed, A
Wort, SJ
Desvergne, B
Garland, C
Zhao, L
Mitchell, JA
Item Type: Journal Article
Publication Date: 2010-03-04
2018-01-16T11:02:17Z
Issue Date: 4-Mar-2010
URI: http://hdl.handle.net/10044/1/56031
DOI: https://dx.doi.org/10.1371/journal.pone.0009526
ISSN: 1932-6203
Publisher: PUBLIC LIBRARY SCIENCE
Journal / Book Title: PLOS ONE
Volume: 5
Issue: 3
Copyright Statement: © 2010 Harrington et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ARTERIAL-HYPERTENSION
PROSTACYCLIN
MODULATION
SURVIVAL
INFLAMMATION
ENDOTHELIUM
RECEPTORS
THERAPY
DISEASE
LIGAND
Administration, Oral
Animals
Cardiomegaly
Hypertension, Pulmonary
Hypoxia
Lung
Male
Mice
Mice, Transgenic
PPAR delta
PPAR-beta
Rats
Rats, Wistar
Thiazoles
rho GTP-Binding Proteins
rhoA GTP-Binding Protein
Lung
Animals
Mice, Transgenic
Mice
Rats
Rats, Wistar
Hypertension, Pulmonary
Cardiomegaly
Thiazoles
rho GTP-Binding Proteins
rhoA GTP-Binding Protein
PPAR-beta
PPAR delta
Administration, Oral
Male
Hypoxia
MD Multidisciplinary
General Science & Technology
Publication Status: Published
Article Number: ARTN e9526
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine



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