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Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-Tube Mass Spectrometry.

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Title: Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-Tube Mass Spectrometry.
Authors: Markar, SR
Chin, S-T
Romano, A
Wiggins, T
Antonowicz, S
Paraskeva, P
Ziprin, P
Darzi, A
Hanna, GB
Item Type: Journal Article
Abstract: OBJECTIVE: BACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer. METHODS: Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS:: CONCLUSION:: This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.
Issue Date: 1-May-2019
Date of Acceptance: 29-Nov-2017
URI: http://hdl.handle.net/10044/1/55901
DOI: https://doi.org/10.1097/SLA.0000000000002539
ISSN: 0003-4932
Publisher: Lippincott, Williams & Wilkins
Start Page: 903
End Page: 910
Journal / Book Title: Annals of Surgery
Volume: 269
Issue: 5
Copyright Statement: This is the accepted version of the article Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-Tube Mass Spectrometry Sheraz R. Markar; Sung-Tong Chin; Andrea Romano; Tom Wiggins; Stefan Antonowicz; Paraskevas Paraskeva; Paul Ziprin; Ara Darzi; George B. Hanna. Annals of Surgery. Publish Ahead of Print():, NOV 2017
Sponsor/Funder: National Institute for Health Research
National Institute of Health Research
Funder's Grant Number: DRF-2014-07-088
Keywords: Science & Technology
Life Sciences & Biomedicine
Surgery
breath
colorectal cancer
diagnosis
recurrence
volatile organic compounds
FECAL OCCULT-BLOOD
EXHALED BREATH
BOWEL-DISEASE
SIFT-MS
IDENTIFICATION
NETWORKS
MARKERS
ONLINE
TESTS
DNA
Surgery
11 Medical and Health Sciences
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer
Institute of Global Health Innovation