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Activity dependent downscaling of subthreshold synaptic inputs during slow wave sleep like activity in vivo

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Title: Activity dependent downscaling of subthreshold synaptic inputs during slow wave sleep like activity in vivo
Authors: González Rueda, A
Pedrosa, V
Feord, R
Clopath, C
Paulsen, O
Item Type: Journal Article
Abstract: Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic homeostasis hypothesis suggests that synaptic connections are strengthened during wake and downscaled during sleep; however, it is not obvious how the same plasticity rules could explain both outcomes. Using whole-cell recordings and optogenetic stimulation of presynaptic input in urethane-anesthetized mice, which exhibit slow-wave-sleep (SWS)-like activity, we show that synaptic plasticity rules are gated by cortical dynamics in vivo. While Down states support conventional spike timing-dependent plasticity, Up states are biased toward depression such that presynaptic stimulation alone leads to synaptic depression, while connections contributing to postsynaptic spiking are protected against this synaptic weakening. We find that this novel activity-dependent and input-specific downscaling mechanism has two important computational advantages: (1) improved signal-to-noise ratio, and (2) preservation of previously stored information. Thus, these synaptic plasticity rules provide an attractive mechanism for SWS-related synaptic downscaling and circuit refinement.
Issue Date: 21-Mar-2018
Date of Acceptance: 10-Jan-2018
URI: http://hdl.handle.net/10044/1/55866
DOI: https://dx.doi.org/10.1016/j.neuron.2018.01.047
ISSN: 0896-6273
Publisher: Elsevier
Start Page: 1244
End Page: 1252.e5
Journal / Book Title: Neuron
Volume: 97
Issue: 6
Copyright Statement: © 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
RAT BARREL CORTEX
SOMATOSENSORY CORTEX
CELL-TYPE
PLASTICITY
DEPRESSION
NEURONS
POTENTIATION
SPIKING
ELECTROENCEPHALOGRAM
HOMEOSTASIS
LTD
LTP
STDP
Up-Down state
in vivo
mouse
network oscillations
sleep
somatosensory cortex
1109 Neurosciences
1702 Cognitive Science
Neurology & Neurosurgery
Publication Status: Published
Online Publication Date: 2018-03-01
Appears in Collections:Faculty of Engineering
Bioengineering



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