Simulating optical coherence tomography for observing nerve activity: a finite difference time domain bi-dimensional model

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Title: Simulating optical coherence tomography for observing nerve activity: a finite difference time domain bi-dimensional model
Authors: Troiani, F
Nikolic, K
Constandinou, TG
Item Type: Working Paper
Abstract: We present a finite difference time domain (FDTD) model for computation of A line scans in time domain optical coherence tomography (OCT). By simulating only the end of the two arms of the interferometer and computing the interference signal in post processing, it is possible to reduce the computational time required by the simulations and, thus, to simulate much bigger environments. Moreover, it is possible to simulate successive A lines and thus obtaining a cross section of the sample considered. In this paper we present the model applied to two different samples: a glass rod filled with water-sucrose solution at different concentrations and a peripheral nerve. This work demonstrates the feasibility of using OCT for non-invasive, direct optical monitoring of peripheral nerve activity, which is a long-sought goal of neuroscience.
Issue Date: 31-Jan-2018
URI: http://hdl.handle.net/10044/1/55740
Copyright Statement: © 2017 The Author(s)
Sponsor/Funder: Engineering & Physical Science Research Council (E
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/K503733/1
BB/L018268/1
4020012831
EP/N002474/1
Keywords: physics.med-ph
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering



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