Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

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Title: Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Author(s): Demenais, F
Margaritte-Jeannin, P
Barnes, KC
Cookson, WOC
Altmüller, J
Ang, W
Barr, RG
Beaty, TH
Becker, AB
Beilby, J
Bisgaard, H
Bjornsdottir, US
Bleecker, E
Bønnelykke, K
Boomsma, DI
Bouzigon, E
Brightling, CE
Brossard, M
Brusselle, GG
Burchard, E
Burkart, KM
Bush, A
Chan-Yeung, M
Chung, KF
Couto Alves, A
Curtin, JA
Custovic, A
Daley, D
De Jongste, JC
Del-Rio-Navarro, BE
Donohue, KM
Duijts, L
Eng, C
Eriksson, JG
Farrall, M
Fedorova, Y
Feenstra, B
Ferreira, MA
Australian Asthma Genetics Consortium (AAGC) collaborators
Freidin, MB
Gajdos, Z
Gauderman, J
Gehring, U
Geller, F
Genuneit, J
Gharib, SA
Gilliland, F
Granell, R
Graves, PE
Gudbjartsson, DF
Haahtela, T
Heckbert, SR
Heederik, D
Heinrich, J
Heliövaara, M
Henderson, J
Himes, BE
Hirose, H
Hirschhorn, JN
Hofman, A
Holt, P
Hottenga, J
Hudson, TJ
Hui, J
Imboden, M
Ivanov, V
Jaddoe, VWV
James, A
Janson, C
Jarvelin, M-R
Jarvis, D
Jones, G
Jonsdottir, I
Jousilahti, P
Kabesch, M
Kähönen, M
Kantor, DB
Karunas, AS
Khusnutdinova, E
Koppelman, GH
Kozyrskyj, AL
Kreiner, E
Kubo, M
Kumar, R
Kumar, A
Kuokkanen, M
Lahousse, L
Laitinen, T
Laprise, C
Lathrop, M
Lau, S
Lee, Y-A
Lehtimäki, T
Letort, S
Levin, AM
Li, G
Liang, L
Loehr, LR
London, SJ
Loth, DW
Manichaikul, A
Marenholz, I
Martinez, FJ
Matheson, MC
Mathias, RA
Matsumoto, K
Mbarek, H
McArdle, WL
Melbye, M
Melén, E
Meyers, D
Michel, S
Mohamdi, H
Musk, AW
Myers, RA
Nieuwenhuis, MAE
Noguchi, E
O'Connor, GT
Ogorodova, LM
Palmer, CD
Palotie, A
Park, JE
Pennell, CE
Pershagen, G
Polonikov, A
Postma, DS
Probst-Hensch, N
Puzyrev, VP
Raby, BA
Raitakari, OT
Ramasamy, A
Rich, SS
Robertson, CF
Romieu, I
Salam, MT
Salomaa, V
Schlünssen, V
Scott, R
Selivanova, PA
Sigsgaard, T
Simpson, A
Siroux, V
Smith, LJ
Solodilova, M
Standl, M
Stefansson, K
Strachan, DP
Stricker, BH
Takahashi, A
Thompson, PJ
Thorleifsson, G
Thorsteinsdottir, U
Tiesler, CMT
Torgerson, DG
Tsunoda, T
Uitterlinden, AG
Van der Valk, RJP
Vaysse, A
Vedantam, S
Von Berg, A
Von Mutius, E
Vonk, JM
Waage, J
Wareham, NJ
Weiss, ST
White, WB
Wickman, M
Widén, E
Willemsen, G
Williams, LK
Wouters, IM
Yang, JJ
Zhao, JH
Moffatt, MF
Ober, C
Nicolae, DL
Item Type: Journal Article
Abstract: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Publication Date: 22-Dec-2017
Date of Acceptance: 8-Nov-2017
URI: http://hdl.handle.net/10044/1/55618
DOI: https://dx.doi.org/10.1038/s41588-017-0014-7
ISSN: 1061-4036
Publisher: Nature Publishing Group
Start Page: 42
End Page: 53
Journal / Book Title: Nature Genetics
Volume: 50
Issue: 1
Copyright Statement: Copyright © 2017, Springer Nature
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/K002449/1
Keywords: Australian Asthma Genetics Consortium (AAGC) collaborators
11 Medical And Health Sciences
06 Biological Sciences
Developmental Biology
Publication Status: Published
Embargo Date: 2018-06-22
Appears in Collections:Infectious Disease Epidemiology
National Heart and Lung Institute
Airway Disease
Department of Medicine
Faculty of Medicine



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