Altmetric

TGF-β signalling pathways in different compartments of the lower airways of stable COPD patients.

File Description SizeFormat 
1-s2.0-S0012369217332853-main.pdfPublished version1.02 MBAdobe PDFView/Open
Title: TGF-β signalling pathways in different compartments of the lower airways of stable COPD patients.
Authors: Di Stefano, A
Sangiorgi, C
Gnemmi, I
Casolari, P
Brun, P
Ricciardolo, FL
Contoli, M
Papi, A
Maniscalco, P
Ruggeri, P
Girbino, G
Cappello, F
Pavlides, S
Guo, Y
Chung, KF
Barnes, PJ
Adcock, IM
Balbi, B
Caramori, G
Item Type: Journal Article
Abstract: BACKGROUND: The expression and localization of transforming growth factor-beta (TGF-β) pathway proteins in different compartments of the lower airways of stable COPD patients is unclear. OBJECTIVE: To determine TGF-β pathway protein expression in patients with stable COPD. METHODS: The expression and localization of TGF-β pathway components was measured in the bronchial mucosa and peripheral lung of patients with stable COPD (n=44), control smokers with normal lung function (n=24) and control non-smoking subjects (n=11) using immunohistochemistry. RESULTS: TGF-β1, TGF-β3 and CCN2 expression were significantly decreased in the bronchiolar epithelium, with TGF-β1 also decreased in alveolar macrophages, of stable COPD patients compared to control smokers with normal lung function. TGF-β3 expression was increased in the bronchial lamina propria of both control smokers with normal lung function and mild/moderate stable COPD compared to control non-smokers and correlated significantly with pack-years. However, TGF-β3+ cells decreased in severe/very severe COPD compared to control smokers. LTBP-1 expression was increased in the bronchial lamina propria in stable COPD of all severities compared with control smokers with normal lung function. BAMBI expression in the bronchial mucosa was significantly increased in stable COPD of all severities compared to control subjects. No other significant differences were observed between groups for all the other molecules studied either in the bronchial mucosa and peripheral lung. CONCLUSION: Expression of TGF-βs and their regulatory proteins is distinct within different lower airway compartments in stable COPD. Selective reduction in TGF-β1 and enhanced BAMBI expression may be associated with the increase in autoimmunity in COPD.
Issue Date: 28-Dec-2017
Date of Acceptance: 1-Dec-2017
URI: http://hdl.handle.net/10044/1/55585
DOI: https://dx.doi.org/10.1016/j.chest.2017.12.017
ISSN: 0012-3692
Publisher: Elsevier
Start Page: 851
End Page: 862
Journal / Book Title: Chest
Volume: 153
Issue: 4
Copyright Statement: © 2018 The Authors. Published by Elsevier Inc under license from the American College of Chest Physicians. his is an open access article under the CC BY license ( http://creativecommons.org/ licenses/by/4.0/ )
Sponsor/Funder: Wellcome Trust
National Institute for Health Research
Funder's Grant Number: 093080/Z/10/Z
NF-SI-0515-10016
Keywords: BAMBI
CTGF
SMAD
TGF-β
airway inflammation
autoimmunity
TGFβ
1103 Clinical Sciences
Respiratory System
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons