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Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.

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Title: Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.
Authors: Srivastava, PK
Roncon, P
Lukasiuk, K
Gorter, JA
Aronica, E
Pitkänen, A
Petretto, E
Johnson, MR
Simonato, M
Item Type: Journal Article
Abstract: The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis, and five differentially expressed in chronic epilepsy. Of these, 13 were not identified in any of the individual studies. To assess the role of these miRNAs, we predicted their mRNA targets and then filtered the list to include only target genes expressed in DG and negatively correlated with miRNA expression. Functional enrichment analysis of mRNA targets of miRNAs dysregulated during epileptogenesis suggested a role for molecular processes related to inflammation and synaptic function. Our results identify new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta-analysis in maximizing value from preclinical data.
Issue Date: 13-Dec-2017
Date of Acceptance: 22-Nov-2017
URI: http://hdl.handle.net/10044/1/55537
DOI: https://dx.doi.org/10.1523/ENEURO.0152-17.2017
ISSN: 2373-2822
Publisher: Society for Neuroscience
Journal / Book Title: eNeuro
Volume: 4
Issue: 6
Copyright Statement: Copyright © 2017 Srivastava et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Keywords: dentate gyrus
epilepsy
hippocampus
mRNA
meta-analysis
miRNA
Publication Status: Published
Article Number: ENEURO.0152-17.2017
Appears in Collections:Clinical Sciences
Molecular Sciences
Department of Medicine
Faculty of Medicine



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