Restorative strategies in movement disorders: the contribution of imaging

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Title: Restorative strategies in movement disorders: the contribution of imaging
Authors: Lao-Kaim, NP
Piccini, P
Tai, YF
Item Type: Journal Article
Abstract: Purpose of Review The purpose of this review was to review the imaging, particularly positron emission tomography (PET), findings in neurorestoration studies in movement disorders, with specific focus on neural transplantation in Parkinson’s disease (PD) and Huntington’s disease (HD). Recent Findings PET findings in PD transplantation studies have shown that graft survival as reflected by increases in dopaminergic PET markers does not necessarily correlate with clinical improvement. PD patients with more denervated ventral striatum and more imbalanced serotonin-to-dopamine ratio in the grafted neurons tended to have worse outcome. In HD transplantation studies, variable graft survival and clinical responses may be related to host inflammatory/immune responses to the grafts. Summary Information gleaned from imaging findings in previous neural transplantation studies has been used to refine study protocol and patient selection in future trials. This includes identifying suitable candidates for transplantation using imaging markers, employing multiple and/or novel PET tracers to better assess graft functions and inflammatory responses to grafts.
Issue Date: 2-Nov-2017
Date of Acceptance: 1-Nov-2017
URI: http://hdl.handle.net/10044/1/55530
DOI: https://dx.doi.org/10.1007/s11910-017-0807-1
ISSN: 1528-4042
Publisher: Current Medicine Group
Journal / Book Title: Current Neurology and Neuroscience Reports
Volume: 17
Issue: 12
Copyright Statement: © The Author(s) 2017. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Parkinson's UK
Funder's Grant Number: H-1503
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Neural transplantation
Emission tomography
Parkinson's
Huntington's
POSITRON-EMISSION-TOMOGRAPHY
FETAL DOPAMINE NEURONS
SEVERE PARKINSONS-DISEASE
ALPHA-SYNUCLEIN DEPOSITION
GRAFT-INDUCED DYSKINESIAS
IN-VIVO VISUALIZATION
LONG-TERM SURVIVAL
HUNTINGTONS-DISEASE
NIGRAL TRANSPLANTATION
NEURAL TRANSPLANTATION
Huntington’s
Parkinson’s
Neurology & Neurosurgery
Publication Status: Published
Article Number: ARTN 98
Appears in Collections:Department of Medicine
Faculty of Medicine



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