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Engineering extracellular vesicles with the tools of enzyme prodrug therapy

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Title: Engineering extracellular vesicles with the tools of enzyme prodrug therapy
Authors: Fuhrmann, G
Chandrawati, R
Parmar, P
Keane, TJ
Maynard, SA
Bertazzo, S
Stevens, MM
Item Type: Journal Article
Abstract: Extracellular vesicles (EVs) have been exploited as drug delivery vehicles but their therapeutic use may be limited due to off-target effects. To harness EVs’inherent properties and to couple them with site-specific drug delivery functions, EVs are incorporated into hydrogels and engineered with the tools of enzyme-prodrug therapy. Local sustained release of anti-inflammatory drugs is demonstrated in macrophage cell models.
Issue Date: 23-Feb-2018
Date of Acceptance: 21-Dec-2017
URI: http://hdl.handle.net/10044/1/55529
DOI: https://dx.doi.org/10.1002/adma.201706616
ISSN: 0935-9648
Publisher: Wiley
Journal / Book Title: Advanced Materials
Volume: 30
Issue: 15
Copyright Statement: © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Commission of the European Communities
Engineering & Physical Science Research Council (EPSRC)
Wellcome Trust
Commission of the European Communities
Commission of the European Communities
Funder's Grant Number: MR/L012677/1
MR/K026682/1
PIIF-GA-2011-299936
EP/K020641/1
098411/Z/12/Z
ERC-2013-CoG-616417
746980
Keywords: enzyme prodrug therapy
exosomes
hydrogels
microvesicles
β-glucuronidase
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Nanoscience & Nanotechnology
Publication Status: Published
Open Access location: http://onlinelibrary.wiley.com/doi/10.1002/adma.201706616/abstract
Article Number: 1706616
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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