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Primary prevention of food allergy: translating evidence from clinical trials to population-based recommendations

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Title: Primary prevention of food allergy: translating evidence from clinical trials to population-based recommendations
Authors: Turner, PJ
Campbell, DE
Boyle, R
Levin, ME
Item Type: Journal Article
Abstract: Given the prevalence and impact of childhood food allergy, there is increasing interest in interventions targeting disease prevention. Although interventions such as early introduction of dietary peanut have demonstrated efficacy in a small number of well-conducted randomized clinical trials, evidence for broader effectiveness and successful implementation at a population level is still lacking, although epidemiological data suggest that such strategies are likely to be successful, at least for peanut. In this commentary, we explore the issues of translating evidence of efficacy studies (performed under optimal conditions) to make policy recommendations at a population level, and highlight potential benefits, harms, and unintended consequences of making population-based recommendations on the basis of randomized controlled trials. We discuss the complexity and barriers to effective primary and secondary prevention intervention implementation in resource-poor settings.
Issue Date: 7-Mar-2018
Date of Acceptance: 15-Dec-2017
URI: http://hdl.handle.net/10044/1/55310
DOI: https://dx.doi.org/10.1016/j.jaip.2017.12.015
ISSN: 2213-2198
Publisher: Elsevier
Start Page: 367
End Page: 375
Journal / Book Title: Journal of Allergy and Clinical Immunology: In Practice
Volume: 6
Issue: 2
Copyright Statement: © 2017 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: MR/K010468/1
RDD02
Keywords: Allergy
Implementation
Peanut
Prevention
Translation
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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