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Towards an MMP-2-activated molecular agent for cancer imaging

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Title: Towards an MMP-2-activated molecular agent for cancer imaging
Authors: Cowell, S
Carroll, L
Lavdas, I
Aboagye, E
Vilar Compte, R
Item Type: Journal Article
Abstract: Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.
Issue Date: 4-Dec-2017
Date of Acceptance: 4-Dec-2017
URI: http://hdl.handle.net/10044/1/55308
DOI: https://dx.doi.org/10.1039/C7DT03108D
ISSN: 1477-9234
Publisher: Royal Society of Chemistry
Start Page: 1530
End Page: 1534
Journal / Book Title: Dalton Transactions
Volume: 47
Copyright Statement: © The Royal Society of Chemistry 2017
Sponsor/Funder: Cancer Research UK
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 10337
EP/H005285/1
Keywords: 0302 Inorganic Chemistry
0399 Other Chemical Sciences
Inorganic & Nuclear Chemistry
Publication Status: Published
Appears in Collections:Division of Surgery
Chemistry
Biological and Biophysical Chemistry
Division of Cancer
Faculty of Medicine
Faculty of Natural Sciences



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