Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases

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Title: Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases
Authors: Jiao, LR
Apostolopoulos, C
Jacob, J
Szydlo, R
Johnson, N
Tsim, N
Habib, NA
Coombes, RC
Stebbing, J
Item Type: Journal Article
Abstract: Purpose There are few data on the impact of immediate and differing surgical interventions on circulating tumor cells (CTCs), nor their compartmentalization or localization in different anatomic vascular sites. Patients and Methods CTCs from consecutive patients with colorectal liver metastases were quantified before and immediately after open surgery, laparoscopic resection, open radiofrequency ablation (RFA), or percutaneous RFA. For individuals undergoing open surgery, either hepatic resections or open RFA, CTCs were examined in both systemic and portal circulation by measuring CTCs in samples derived from the peripheral vein, an artery, the hepatic portal vein, and the hepatic vein. Results A total of 29 consecutive patients with colorectal liver metastases with a median age of 55 years (range, 30 to 88 years) were included. CTCs were localized to the hepatic portosystemic macrocirculation with significantly greater numbers than in the systemic vasculature. Surgical procedures led to a statistically significant fall in CTCs at multiple sites measured. Conversely, RFA, either open or percutaneous, was associated with a significant increase in CTCs. Conclusion Surgical resection of metastases, but not RFA, immediately decreases CTC levels. In patients with colorectal liver metastases, CTCs appear localized to the hepatic (and pulmonary) macrocirculations. This may explain why metastases in sites other than the liver and lungs are infrequently observed in cancer.
Issue Date: 20-Dec-2009
Date of Acceptance: 4-Aug-2009
URI: http://hdl.handle.net/10044/1/54826
DOI: https://dx.doi.org/10.1200/JCO.2009.24.5837
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology
Start Page: 6160
End Page: 6165
Journal / Book Title: Journal of Clinical Oncology
Volume: 27
Issue: 36
Copyright Statement: © 2009 by American Society of Clinical Oncology
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
BREAST-CANCER PATIENTS
RADIOFREQUENCY ABLATION
REPORTING RECOMMENDATIONS
PROGNOSTIC-SIGNIFICANCE
SYSTEMIC THERAPY
BONE-MARROW
RESECTION
SURVIVAL
BLOOD
CARCINOMA
Adult
Aged
Aged, 80 and over
Catheter Ablation
Colorectal Neoplasms
Combined Modality Therapy
Female
Humans
Liver Circulation
Liver Neoplasms
Male
Middle Aged
Neoplastic Cells, Circulating
Prognosis
Survival Rate
Treatment Outcome
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Department of Medicine
Faculty of Medicine



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