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Influenza burden, prevention and treatment in asthma - a scoping review by the EAACI Influenza in Asthma Task Force

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Title: Influenza burden, prevention and treatment in asthma - a scoping review by the EAACI Influenza in Asthma Task Force
Authors: Schwarze, J
Openshaw, P
Jha, A
Del Giacco, SR
Firinu, D
Tsilochristou, O
Roberts, G
Selby, A
Akdis, C
Agache, I
Custovic, A
Heffler, E
Pinna, G
Khaitov, M
Nikonova, A
Papadopoulos, N
Akhlaq, A
Nurmatov, U
Renz, H
Sheikh, A
Skevaki, C
Item Type: Journal Article
Abstract: To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma. This article is protected by copyright. All rights reserved.
Issue Date: 1-Jun-2018
Date of Acceptance: 6-Nov-2017
URI: http://hdl.handle.net/10044/1/54810
DOI: https://dx.doi.org/10.1111/all.13333
ISSN: 0105-4538
Publisher: Wiley
Start Page: 1151
End Page: 1181
Journal / Book Title: Allergy
Volume: 73
Copyright Statement: © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13333
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Imperial College Healthcare Trust Biomedical Research Centre (BRC)
Funder's Grant Number: G1000758
G1000758
MR/L012693/1
P45058
Keywords: antivirals
heath care utilization
respiratory
vaccination
viral infection
Viral infection
1107 Immunology
Allergy
Publication Status: Published
Conference Place: Denmark
Open Access location: http://onlinelibrary.wiley.com/doi/10.1111/all.13333/full
Online Publication Date: 2017-11-06
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine



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