Describing Genomic and Epigenomic Traits Underpinning Emerging Fungal Pathogens.

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Title: Describing Genomic and Epigenomic Traits Underpinning Emerging Fungal Pathogens.
Author(s): Farrer, RA
Fisher, MC
Item Type: Journal Article
Abstract: An unprecedented number of pathogenic fungi are emerging and causing disease in animals and plants, putting the resilience of wild and managed ecosystems in jeopardy. While the past decades have seen an increase in the number of pathogenic fungi, they have also seen the birth of new big data technologies and analytical approaches to tackle these emerging pathogens. We review how the linked fields of genomics and epigenomics are transforming our ability to address the challenge of emerging fungal pathogens. We explore the methodologies and bioinformatic toolkits that currently exist to rapidly analyze the genomes of unknown fungi, then discuss how these data can be used to address key questions that shed light on their epidemiology. We show how genomic approaches are leading a revolution into our understanding of emerging fungal diseases and speculate on future approaches that will transform our ability to tackle this increasingly important class of emerging pathogens.
Publication Date: 28-Oct-2017
Date of Acceptance: 28-Oct-2017
URI: http://hdl.handle.net/10044/1/54787
DOI: https://dx.doi.org/10.1016/bs.adgen.2017.09.009
ISSN: 0065-2660
Publisher: Elsevier
Start Page: 73
End Page: 140
Journal / Book Title: Advances in Genetics
Volume: 100
Sponsor/Funder: Medical Research Council (MRC)
Natural Environment Research Council (NERC)
The Leverhulme Trust
Natural Environment Research Council (NERC)
Funder's Grant Number: MR/K000373/1
NE/K014455/1
RPG-2014-273
NE/P001165/1
Copyright Statement: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Emerging fungal pathogen
Epidemiology
Epigenome
Genome
Emerging fungal pathogen
Epidemiology
Epigenome
Genome
Developmental Biology
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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