Focal Ablation of Early-Stage Prostate Cancer: Candidate Selection, Treatment Guidance, and Assessment of Outcome.

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Title: Focal Ablation of Early-Stage Prostate Cancer: Candidate Selection, Treatment Guidance, and Assessment of Outcome.
Author(s): Edison, E
Tariq Shah, T
Ahmed, HU
Item Type: Journal Article
Abstract: Prostate cancer lesions smaller than 0.5 m3, or Gleason pattern 3, are likely clinically insignificant. Clinically significant disease is often limited to a single index lesion. Focal ablation targets this index lesion, maintains oncological control, and minimizes complications by preserving healthy prostate tissue. Template mapping biopsy or multiparametric MRI-targeted biopsies are used to identify appropriate index lesions. Multiple energy modalities have been tested, including high-intensity frequency ultrasound, cryoablation, laser ablation, photodynamic therapy, focal brachytherapy, radiofrequency ablation, irreversible electroporation. Outcome is assessed by biopsy of the target area, triggered by prostate-specific antigen measurements or MRI imaging, or performed per protocol at 12 months.
Publication Date: 27-Oct-2017
Date of Acceptance: 27-Oct-2017
URI: http://hdl.handle.net/10044/1/54609
DOI: https://dx.doi.org/10.1016/j.ucl.2017.07.006
ISSN: 0094-0143
Publisher: WB Saunders
Start Page: 575
End Page: 585
Journal / Book Title: Urologic Clinics of North America
Volume: 44
Issue: 4
Copyright Statement: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Wellcome Trust
University College London Hospitals Charity
Funder's Grant Number: 204998/Z/16/Z
1348
Keywords: Cryotherapy
High-intensity focused ultrasound ablation
Laser therapy
Photodynamic therapy
Prostate cancer
Ablation Techniques
Biopsy
Humans
Magnetic Resonance Imaging
Male
Neoplasm Grading
Patient Selection
Practice Guidelines as Topic
Prostatic Neoplasms
Treatment Outcome
Humans
Prostatic Neoplasms
Magnetic Resonance Imaging
Biopsy
Treatment Outcome
Patient Selection
Male
Practice Guidelines as Topic
Ablation Techniques
Neoplasm Grading
Cryotherapy
High-intensity focused ultrasound ablation
Laser therapy
Photodynamic therapy
Prostate cancer
Ablation Techniques
Biopsy
Humans
Magnetic Resonance Imaging
Male
Neoplasm Grading
Patient Selection
Practice Guidelines as Topic
Prostatic Neoplasms
Treatment Outcome
1103 Clinical Sciences
Urology & Nephrology
Publication Status: Published
Embargo Date: 2018-10-27
Appears in Collections:Division of Surgery
Faculty of Medicine



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