Globally Efficient Brain Organization and Treatment Response in Psychosis: A Connectomic Study of Gyrification

Title: Globally Efficient Brain Organization and Treatment Response in Psychosis: A Connectomic Study of Gyrification
Author(s): Palaniyappan, L
Marques, TR
Taylor, H
Mondelli, V
Reinders, AATS
Bonaccorso, S
Giordano, A
DiForti, M
Simmons, A
David, AS
Pariante, CM
Murray, RM
Dazzan, P
Item Type: Journal Article
Abstract: Background: Converging evidence suggests that patients with first-episode psychosis who show a poor treatment response may have a higher degree of neurodevelopmental abnormalities than good Responders. Characterizing the disturbances in the relationship among brain regions (covariance) can provide more information on neurodevelopmental integrity than searching for localized changes in the brain. Graph-based connectomic approach can measure structural covariance thus providing information on the maturational processes. We quantified the structural covariance of cortical folding using graph theory in first-episode psychosis, to investigate if this systems-level approach would improve our understanding of the biological determinants of outcome in psychosis. Methods: Magnetic Resonance Imaging data were acquired in 80 first-episode psychosis patients and 46 healthy controls. Response to treatment was assessed after 12 weeks of naturalistic follow-up. Gyrification-based connectomes were constructed to study the maturational organization of cortical folding. Results: Nonresponders showed a reduction in the distributed relationship among brain regions (high segregation, poor integration) when compared to Responders and controls, indicating a higher burden of aberrant neurodevelopment. They also showed reduced centrality of key regions (left insula and anterior cingulate cortex) indicating a marked reconfiguration of gyrification. Nonresponders showed a vulnerable pattern of covariance that disintegrated when simulated lesions removed high-degree hubs, indicating an abnormal dependence on highly central hub regions in Nonresponders. Conclusions: These findings suggest that a perturbed maturational relationship among brain regions underlies poor treatment response in first-episode psychosis. The information obtained from gyrification-based connectomes can be harnessed for prospectively predicting treatment response and prognosis in psychosis.
Publication Date: 28-Jun-2016
Date of Acceptance: 28-Jun-2016
URI: http://hdl.handle.net/10044/1/54564
DOI: https://dx.doi.org/10.1093/schbul/sbw069
ISSN: 1745-1701
Publisher: Oxford University Press (OUP)
Start Page: 1446
End Page: 1456
Journal / Book Title: Schizophrenia Bulletin
Volume: 42
Issue: 6
Copyright Statement: © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Keywords: Science & Technology
Life Sciences & Biomedicine
Psychiatry
cortical folding
connectome
graph theory
neuroimaging
first-episode psychosis
surface based morphometry
GRAPH-THEORETICAL ANALYSIS
NEUROLOGICAL SOFT SIGNS
HUMAN CORTICAL NETWORKS
SMALL-WORLD NETWORKS
FUNCTIONAL CONNECTIVITY
SCHIZOPHRENIA-PATIENTS
1ST-EPISODE PSYCHOSIS
STRUCTURAL COVARIANCE
ANATOMICAL NETWORKS
REGIONS
connectome
cortical folding
first-episode psychosis
graph theory
neuroimaging
surface based morphometry
Adult
Antipsychotic Agents
Cerebral Cortex
Connectome
Female
Humans
Magnetic Resonance Imaging
Male
Outcome Assessment (Health Care)
Psychotic Disorders
Young Adult
Cerebral Cortex
Humans
Antipsychotic Agents
Magnetic Resonance Imaging
Psychotic Disorders
Adult
Outcome Assessment (Health Care)
Female
Male
Young Adult
Connectome
Science & Technology
Life Sciences & Biomedicine
Psychiatry
cortical folding
connectome
graph theory
neuroimaging
first-episode psychosis
surface based morphometry
GRAPH-THEORETICAL ANALYSIS
NEUROLOGICAL SOFT SIGNS
HUMAN CORTICAL NETWORKS
SMALL-WORLD NETWORKS
FUNCTIONAL CONNECTIVITY
SCHIZOPHRENIA-PATIENTS
1ST-EPISODE PSYCHOSIS
STRUCTURAL COVARIANCE
ANATOMICAL NETWORKS
REGIONS
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Psychiatry
Publication Status: Published
Appears in Collections:Clinical Sciences
Imaging Sciences
Faculty of Medicine



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