A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers

Title: A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers
Author(s): Lawrence, E
Vegvari, C
Ower, A
Hadjichrysanthou, C
De Wolf, F
Anderson, RM
Item Type: Journal Article
Abstract: Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease, with no effective treatment or cure. A gold standard therapy would be treatment to slow or halt disease progression; however, knowledge of causation in the early stages of AD is very limited. In order to determine effective endpoints for possible therapies, a number of quantitative surrogate markers of disease progression have been suggested, including biochemical and imaging biomarkers. The dynamics of these various surrogate markers over time, particularly in relation to disease development, are, however, not well characterized. We reviewed the literature for studies that measured cerebrospinal fluid or plasma amyloid-and tau, or took magnetic resonance image or fluorodeoxyglucose/Pittsburgh compound B-positron electron tomography scans, in longitudinal cohort studies. We summarized the properties of the major cohort studies in various countries, commonly used diagnosis methods and study designs. We have concluded that additional studies with repeat measures over time in a representative population cohort are needed to address the gap in knowledge of AD progression. Based on our analysis, we suggest directions in which research could move in order to advance our understanding of this complex disease, including repeat biomarker measurements, standardization and increased sample sizes.
Publication Date: 14-Aug-2017
Date of Acceptance: 14-Jun-2017
URI: http://hdl.handle.net/10044/1/54562
DOI: https://dx.doi.org/10.3233/JAD-170261
ISSN: 1387-2877
Publisher: IOS Press
Start Page: 1359
End Page: 1379
Journal / Book Title: JOURNAL OF ALZHEIMERS DISEASE
Volume: 59
Issue: 4
Copyright Statement: © IOS Press and the Authors. CC BY NC
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
biomarker
cross-sectional
dementia
longitudinal
MILD COGNITIVE IMPAIRMENT
WHITE-MATTER HYPERINTENSITIES
PLASMA AMYLOID-BETA
POSITRON-EMISSION-TOMOGRAPHY
MULTICENTER CLINICAL-TRIALS
TENSOR-BASED MORPHOMETRY
PITTSBURGH COMPOUND-B
BRAIN VOLUME CHANGES
CEREBROSPINAL-FLUID
HIPPOCAMPAL ATROPHY
Alzheimer’s disease
biomarker
cross-sectional
dementia
longitudinal
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
biomarker
cross-sectional
dementia
longitudinal
MILD COGNITIVE IMPAIRMENT
WHITE-MATTER HYPERINTENSITIES
PLASMA AMYLOID-BETA
POSITRON-EMISSION-TOMOGRAPHY
MULTICENTER CLINICAL-TRIALS
TENSOR-BASED MORPHOMETRY
PITTSBURGH COMPOUND-B
BRAIN VOLUME CHANGES
CEREBROSPINAL-FLUID
HIPPOCAMPAL ATROPHY
1103 Clinical Sciences
1702 Cognitive Science
1109 Neurosciences
Neurology & Neurosurgery
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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