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Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

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Kluzek et al. 2017, Soft Matter_accepted manuscript.pdfAccepted version9.02 MBAdobe PDFView/Open
Title: Influence of a pH-sensitive polymer on the structure of monoolein cubosomes
Authors: Kluzek, M
Tyler, AII
Wang, S
Chen, R
Marques, CM
Thalmann, F
Seddon, JM
Schmutz, M
Item Type: Journal Article
Abstract: Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceutical and cosmetic applications, and efforts are currently being made to control the encapsulation and release properties of these colloidal objects. We overcome in this work the lack of sensitivity of monoolein cubosomes to pH conditions by using a pH sensitive polymer designed to strongly interact with the lipid structure at low pH. Our cryo-transmission electron microscope (cryo-TEM) and small-angle X-ray scattering (SAXS) results show that in the presence of the polymer the cubic phase structure is preserved at neutral pH, albeit with a larger cell size. At pH 5.5, in the presence of the polymer, the nanostructure of the cubosome particles is significantly altered, providing a pathway to design pH-responsive cubosomes for applications in drug delivery.
Issue Date: 2-Oct-2017
Date of Acceptance: 30-Sep-2017
URI: http://hdl.handle.net/10044/1/54032
DOI: https://dx.doi.org/10.1039/c7sm01620d
ISSN: 1744-683X
Publisher: Royal Society of Chemistry
Start Page: 7571
End Page: 7577
Journal / Book Title: Soft Matter
Volume: 13
Copyright Statement: © The Royal Society of Chemistry 2017
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Physical
Materials Science, Multidisciplinary
Physics, Multidisciplinary
Polymer Science
Chemistry
Materials Science
Physics
LYOTROPIC LIQUID-CRYSTALS
BICONTINUOUS CUBIC PHASE
DRUG-DELIVERY SYSTEMS
RESPONSIVE POLYMERS
WATER CHANNELS
X-RAY
DISPERSIONS
RELEASE
MEMBRANE
DIOLEOYLPHOSPHATIDYLSERINE/MONOOLEIN
03 Chemical Sciences
09 Engineering
02 Physical Sciences
Chemical Physics
Publication Status: Published
Conference Place: England
Appears in Collections:Faculty of Engineering
Chemistry
Chemical Engineering
Faculty of Natural Sciences



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