A redox-activated G-quadruplex DNA binder based on a platinum(IV)-salphen complex.

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Title: A redox-activated G-quadruplex DNA binder based on a platinum(IV)-salphen complex.
Author(s): Vilar, R
Bandeira, S
Gonzalez Garcia, J
Pensa, E
Albrecht, T
Item Type: Journal Article
Abstract: There has been increasing interest in the development of small molecules that can selectively bind to G-quadruplex DNA structures. The latter have been associated to a number of key biological processes and therefore are proposed to be potential targets for drug development. In this paper we report the first example of a reduction-activated G-quadruplex DNA binder. We show that a new octahedral platinum(IV)-salphen complex does not interact with DNA in aqueous media at pH 7.4; however, upon addition of bio-reductants such as ascorbic acid or glutathione, the compound readily reduces to the corresponding square planar platinum(II) complex. In contrast to the parent platinum(IV) complex, the in situ generated platinum(II) complex binds to HTelo and c-Myc G-quadruplex DNA with affinity constants up to 106 M-1.
Publication Date: 17-Nov-2017
Date of Acceptance: 16-Nov-2017
URI: http://hdl.handle.net/10044/1/54030
DOI: https://dx.doi.org/10.1002/anie.201709968
ISSN: 1521-3757
Publisher: Wiley
Start Page: 310
End Page: 313
Journal / Book Title: Angewandte Chemie International Edition
Volume: 57
Issue: 1
Copyright Statement: This is the peer reviewed version of the following article: Vilar, R., Bandeira, S., Gonzalez Garcia, J., Pensa, E. and Albrecht, T. (), A redox-activated G-quadruplex DNA binder based on a platinum(IV)-salphen complex. Angew. Chem. Int. Ed.. Accepted Author Manuscript, which has been published in final form at https://dx.doi.org/10.1002/anie.201709968. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Keywords: DNA structures
G-quadruplexes
antitumor agents
drug targeting
platinum
Platinum Quadruplex DNA Luminescence DNA binding Redox activated
03 Chemical Sciences
Organic Chemistry
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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