3'-Deoxy-3'-[(18)F]Fluorothymidine uptake is related to thymidine phosphorylase expression in various experimental tumor models

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Title: 3'-Deoxy-3'-[(18)F]Fluorothymidine uptake is related to thymidine phosphorylase expression in various experimental tumor models
Author(s): Schelhaas, S
Heinzmann, K
Honess, DJ
Smith, D-M
Keen, H
Heskamp, S
Witney, TH
Besret, L
Doblas, S
Griffiths, JR
Aboagye, EO
Jacobs, AH
Item Type: Journal Article
Abstract: PURPOSE: We recently reported that high thymidine phosphorylase (TP) expression is accompanied by low tumor thymidine concentration and high 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) uptake in four untreated lung cancer xenografts. Here, we investigated whether this relationship also holds true for a broader range of tumor models. PROCEDURES: Lysates from n = 15 different tumor models originating from n = 6 institutions were tested for TP and thymidylate synthase (TS) expression using western blots. Results were correlated to [(18)F]FLT accumulation in the tumors as determined by positron emission tomography (PET) measurements in the different institutions and to previously published thymidine concentrations. RESULTS: Expression of TP correlated positively with [(18)F]FLT SUVmax (ρ = 0.549, P < 0.05). Furthermore, tumors with high TP levels possessed lower levels of thymidine (ρ = - 0.939, P < 0.001). CONCLUSIONS: In a broad range of tumors, [(18)F]FLT uptake as measured by PET is substantially influenced by TP expression and tumor thymidine concentrations. These data strengthen the role of TP as factor confounding [(18)F]FLT uptake.
Publication Date: 2-Oct-2017
Date of Acceptance: 1-Oct-2017
URI: http://hdl.handle.net/10044/1/53971
DOI: https://dx.doi.org/10.1007/s11307-017-1125-3
ISSN: 1536-1632
Publisher: Springer Verlag
Journal / Book Title: Molecular Imaging and Biology
Copyright Statement: © World Molecular Imaging Society 2017. The final publication is available at Springer via https://link.springer.com/article/10.1007/s11307-017-1125-3
Keywords: Oncology
PET
Thymidine phosphorylase
[18F]FLT
Oncology
PET
Thymidine phosphorylase
[18F]FLT
1103 Clinical Sciences
0606 Physiology
Nuclear Medicine & Medical Imaging
Publication Status: Published
Conference Place: United States
Embargo Date: 2018-10-02
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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