Modelling firing regularity in the ventral cochlear nucleus: Mechanisms, and effects of stimulus level and synaptopathy.

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Title: Modelling firing regularity in the ventral cochlear nucleus: Mechanisms, and effects of stimulus level and synaptopathy.
Author(s): Goodman, DFM
Winter, IM
Léger, AC
De Cheveigné, A
Lorenzi, C
Item Type: Journal Article
Abstract: The auditory system processes temporal information at multiple scales, and disruptions to this temporal processing may lead to deficits in auditory tasks such as detecting and discriminating sounds in a noisy environment. Here, a modelling approach is used to study the temporal regularity of firing by chopper cells in the ventral cochlear nucleus, in both the normal and impaired auditory system. Chopper cells, which have a strikingly regular firing response, divide into two classes, sustained and transient, based on the time course of this regularity. Several hypotheses have been proposed to explain the behaviour of chopper cells, and the difference between sustained and transient cells in particular. However, there is no conclusive evidence so far. Here, a reduced mathematical model is developed and used to compare and test a wide range of hypotheses with a limited number of parameters. Simulation results show a continuum of cell types and behaviours: chopper-like behaviour arises for a wide range of parameters, suggesting that multiple mechanisms may underlie this behaviour. The model accounts for systematic trends in regularity as a function of stimulus level that have previously only been reported anecdotally. Finally, the model is used to predict the effects of a reduction in the number of auditory nerve fibres (deafferentation due to, for example, cochlear synaptopathy). An interactive version of this paper in which all the model parameters can be changed is available online.
Publication Date: 20-Sep-2017
Date of Acceptance: 18-Sep-2017
URI: http://hdl.handle.net/10044/1/53954
DOI: https://dx.doi.org/10.1016/j.heares.2017.09.010
ISSN: 0378-5955
Publisher: Elsevier
Journal / Book Title: Hearing Research
Copyright Statement: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Chopper cell
Computational model
Deafferentation
Regularity
Ventral cochlear nucleus
Chopper cell
Computational model
Deafferentation
Regularity
Ventral cochlear nucleus
1103 Clinical Sciences
1109 Neurosciences
1116 Medical Physiology
Otorhinolaryngology
Publication Status: Published online
Embargo Date: 2018-09-20
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering



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