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Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness

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Title: Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness
Authors: Edwards, MR
Strong, K
Cameron, A
Walton, RP
Jackson, DJ
Johnston, SL
Item Type: Journal Article
Abstract: Viral respiratory tract infections are associated with asthma inception in early life and asthma exacerbations in older children and adults. Although how viruses influence asthma inception is poorly understood, much research has focused on the host response to respiratory viruses and how viruses can promote; or how the host response is affected by subsequent allergen sensitization and exposure. This review focuses on the innate interferon-mediated host response to respiratory viruses and discusses and summarizes the available evidence that this response is impaired or suboptimal. In addition, the ability of respiratory viruses to act in a synergistic or additive manner with TH2 pathways will be discussed. In this review we argue that these 2 outcomes are likely linked and discuss the available evidence that shows reciprocal negative regulation between innate interferons and TH2 mediators. With the renewed interest in anti-TH2 biologics, we propose a rationale for why they are particularly successful in controlling asthma exacerbations and suggest ways in which future clinical studies could be used to find direct evidence for this hypothesis.
Issue Date: 4-Oct-2017
Date of Acceptance: 31-Jul-2017
URI: http://hdl.handle.net/10044/1/53933
DOI: https://dx.doi.org/10.1016/j.jaci.2017.07.025
ISSN: 0091-6749
Publisher: MOSBY-ELSEVIER
Start Page: 909
End Page: 920
Journal / Book Title: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume: 140
Issue: 4
Copyright Statement: © 2017 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Sponsor/Funder: Asthma UK
Funder's Grant Number: Asthma UK Centre
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
Virus
allergic inflammation
interferon
asthma
T-H(2)
RESPIRATORY SYNCYTIAL VIRUS
INNATE IMMUNE-RESPONSES
BRONCHIAL EPITHELIAL-CELLS
CYTOKINE SIGNALING 1
PLASMACYTOID DENDRITIC CELLS
SEVERE EOSINOPHILIC ASTHMA
RHINOVIRUS-INDUCED ASTHMA
PLACEBO-CONTROLLED TRIAL
BLOOD MONONUCLEAR-CELLS
HOSPITAL ADMISSIONS
T(H)2
Allergy and Immunology
Animals
Disease Progression
Humans
Hypersensitivity
Inflammation
Interferons
Respiratory Tract Infections
Th2 Cells
Virus Diseases
1107 Immunology
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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