Low-Noise Plasmonic Nanopore Biosensors for Single Molecule Detection at Elevated Temperatures

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Title: Low-Noise Plasmonic Nanopore Biosensors for Single Molecule Detection at Elevated Temperatures
Authors: Crick, CR
Albella, P
Kim, H-J
Ivanov, AP
Kim, K-B
Maier, SA
Edel, JB
Item Type: Journal Article
Abstract: Advanced single molecular analysis is a key stepping stone for the rapid sensing and characterization of biomolecules. This will only be made possible through the implementation of versatile platforms, with high sensitivities and the precise control of experimental conditions. The presented work details an advancement of this technology, through the development of a low-noise Pyrex/silicon nitride/gold nanopore platform. The nanopore is surrounded by a plasmonic bullseye structure and provides targeted and controllable heating via laser irradiation, which is directed toward the center of the pore. The device architecture is investigated using multiwavelength laser heating experiments and 'individual DNA molecules are detected under controlled heating. The plasmonic features, optimized through numerical simulations, are tuned to the wavelength of incident light, ensuring a platform that provides substantial heating with high signal-to-noise.
Issue Date: 16-Oct-2017
Date of Acceptance: 26-Sep-2017
URI: http://hdl.handle.net/10044/1/53813
DOI: https://dx.doi.org/10.1021/acsphotonics.7b00825
ISSN: 2330-4022
Publisher: American Chemical Society
Start Page: 2835
End Page: 2842
Journal / Book Title: ACS Photonics
Volume: 4
Issue: 11
Copyright Statement: Copyright © 2017 American Chemical Society
Sponsor/Funder: Commission of the European Communities
Commission of the European Communities
Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Funder's Grant Number: 279818
Publication Status: Published
Appears in Collections:Chemistry
Faculty of Natural Sciences

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