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Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.

Title: Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.
Authors: Chung, F
Item Type: Journal Article
Abstract: Interleukin-10 (IL-10) is a cytokine derived from CD4+ T-helper type 2 (T(H2)) cells identified as a suppressor of cytokines from T-helper type 1(T(H1)) cells. Interleukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates T(H1) cell differentiation, while suppressing the expansion of T(H2) cell clones. Interferon-gamma (IFN-gamma) is a product of T(H1) cells and exerts inhibitory effects on T(H2) cell differentiation. These cytokines have been implicated in the pathogenesis of asthma and allergies. In this context, IL-12 and IFN-gamma production in asthma have been found to be decreased, and this may reduce their capacity to inhibit IgE synthesis and allergic inflammation. IL-10 is a potent inhibitor of monocyte/macrophage function, suppressing the production of many pro-inflammatory cytokines. A relative underproduction of IL-10 from alveolar macrophages of atopic asthmatics has been reported. Therapeutic modulation of T(H1)/T(H2) imbalance in asthma and allergy by mycobacterial vaccine, specific immunotherapy and cytoline-guanosine dinucleotide motif may lead to increases in IL-12 and IFN-gamma production. Stimulation of IL-10 production by antigen-specific T-cells during immunotherapy may lead to anergy through inhibition of CD28-costimulatory molecule signalling by IL-10s anti-inflammatory effect on basophils, mast cells and eosinophils.
Issue Date: 30-Apr-2001
URI: http://hdl.handle.net/10044/1/53775
DOI: https://dx.doi.org/10.1080/09629350120054518
ISSN: 0962-9351
Start Page: 51
End Page: 59
Journal / Book Title: Mediators Inflamm
Volume: 10
Issue: 2
Copyright Statement: © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Asthma
Cytokines
Humans
Hypersensitivity
Interferon-gamma
Interleukin-10
Interleukin-12
T-Lymphocytes, Helper-Inducer
Th1 Cells
Th2 Cells
1107 Immunology
Immunology
Publication Status: Published
Conference Place: United States
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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