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The Respiratory Microbiome In Idiopathic Pulmonary Fibrosis

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Title: The Respiratory Microbiome In Idiopathic Pulmonary Fibrosis
Authors: Molyneaux, PL
Russell, AM
Cox, MJ
Moffatt, MF
Cookson, WO
Maher, TM
Item Type: Journal Article
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease of unknown cause. Current evidence suggests that it arises in genetically susceptible individuals as a consequence of an aberrant wound-healing response following repetitive alveolar injury. Overt respiratory infection and immunosuppression carry a high mortality, while polymorphisms in genes related to epithelial integrity and host defence predispose to IPF. Recent advances in sequencing technologies have allowed the use of molecular microbial technologies to characterise the respiratory microbiota in patients with IPF. Studies have suggested that changes in the overall bacterial burden are related to disease progression and highlighted significant differences between the microbiota in IPF subjects and healthy controls. Indeed differences in the microbiota between IPF patients may differentiate those with stable compared to progressive disease. As our understanding of the IPF microbiome evolves, along with refinement and advances in sampling and sequencing methodologies we may be able to use microbial signatures as a biomarker to guide prognostication and even treatment stratification in this devastating disease.
Issue Date: 1-Jun-2017
Date of Acceptance: 30-Nov-2016
URI: http://hdl.handle.net/10044/1/53675
DOI: https://dx.doi.org/10.21037/atm.2017.01.56
ISSN: 2305-5839
Publisher: AME Publishing Company
Journal / Book Title: Annals of translational medicine
Volume: 5
Issue: 12
Copyright Statement: © Annals of Translational Medicine. All rights reserved.
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
Idiopathic pulmonary fibrosis (IPF)
microbiome
infection
16S
INTERSTITIAL LUNG-DISEASE
GENOME-WIDE ASSOCIATION
PROMOTER POLYMORPHISM
PATHOGENESIS
BACTERIA
PROGRESSION
INFECTION
SUSCEPTIBILITY
IDENTIFICATION
COMMUNITIES
Publication Status: Published
Article Number: 250
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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