The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study

Title: The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study
Authors: Stebbing, J
Payne, R
Reise, J
Frampton, AE
Avery, M
Woodley, L
Di Leo, A
Pestrin, M
Krell, J
Coombes, RC
Item Type: Journal Article
Issue Date: 7-May-2013
URI: http://hdl.handle.net/10044/1/53532
DOI: https://dx.doi.org/10.1371/journal.pone.0062543
ISSN: 1932-6203
Publisher: PUBLIC LIBRARY SCIENCE
Journal / Book Title: PLOS ONE
Volume: 8
Issue: 5
Copyright Statement: 2013 Stebbing et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Cancer Research UK
National Institute for Health Research
Cancer Research UK
Funder's Grant Number: C37/A12011
NIHR-RP-011-053
14549
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
ESTROGEN-RECEPTOR
RANDOMIZED-TRIAL
DISEASE PROGRESSION
1ST-LINE TREATMENT
SOLID TUMORS
DOUBLE-BLIND
CROSS-TALK
PHASE-II
PLACEBO
GEFITINIB
Adult
Aged
Breast Neoplasms
Gene Amplification
Humans
Middle Aged
Neoplastic Cells, Circulating
Quinazolines
Receptor, Epidermal Growth Factor
Receptor, ErbB-2
Receptor, erbB-2
MD Multidisciplinary
General Science & Technology
Publication Status: Published
Article Number: ARTN e62543
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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