A dedicated neonatal brain imaging system

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Title: A dedicated neonatal brain imaging system
Author(s): Hughes, EJ
Winchman, T
Padormo, F
Teixeira, R
Wurie, J
Sharma, M
Fox, M
Hutter, J
Cordero-Grande, L
Price, AN
Allsop, J
Bueno-Conde, J
Tusor, N
Arichi, T
Edwards, AD
Rutherford, MA
Counsell, SJ
Hajnal, JV
Item Type: Journal Article
Abstract: Purpose The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges. Methods We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil. Results The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate. Conclusion The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates. Magn Reson Med 78:794–804, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Publication Date: 13-Jul-2017
Date of Acceptance: 20-Aug-2016
URI: http://hdl.handle.net/10044/1/53493
DOI: https://dx.doi.org/10.1002/mrm.26462
ISSN: 0740-3194
Publisher: Wiley
Start Page: 794
End Page: 804
Journal / Book Title: Magnetic Resonance in Medicine
Volume: 78
Issue: 2
Copyright Statement: © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
neonatal
brain
head coil
unsedated
PROSPECTIVE MOTION
MRI
SEDATION
ARRAYS
brain
head coil
neonatal
unsedated
Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
neonatal
brain
head coil
unsedated
PROSPECTIVE MOTION
MRI
SEDATION
ARRAYS
0903 Biomedical Engineering
Nuclear Medicine & Medical Imaging
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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