Fasting plasma glucose and variation in cardiometabolic risk factors in people with high-risk HbA1c-defined prediabetes: a cross-sectional multiethnic study.

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Title: Fasting plasma glucose and variation in cardiometabolic risk factors in people with high-risk HbA1c-defined prediabetes: a cross-sectional multiethnic study.
Authors: Srivanichakorn, W
Godsland, IF
Thomson, H
Misra, S
Phisalprapa, P
Charatcharoenwitthaya, P
Pramyothin, P
Washirasaksiri, C
Snehalatha, C
Ramachandran, A
George Mm Alberti, K
Johnston, DG
Oliver, NS
Item Type: Journal Article
Abstract: AIMS: Variation in cardiometabolic risk in prediabetes and any impacts of ethnicity on such variation have been little studied. In an ethnically diverse dataset, selected according to a high-risk HbA1c-based definition of prediabetes, we have investigated relationships between glycaemia and cardiometabolic risk factors and the influence of ethnicity on these relationships. METHODS: We undertook a cross-sectional analysis of baseline data from a diabetes prevention study in the UK and a chronic care clinic in Thailand, selected for people without diabetes (fasting plasma glucose <7.0 mmol/l) with HbA1c 6.0% - 6.4% (42-47 mmol/mol). Thai (n=158) and UK White (n=600), South Asian (n=112), Black (n=70) and other/mixed (n=103) groups were distinguished and measurements included fasting plasma glucose (FPG), blood pressure (BP), lipids and insulin resistance-related risk factors (IRFs). RESULTS: Independently of individual characteristics including ethnicity, only systolic BP was weakly associated with FPG (beta coefficient 1.76 (95%CI 0.10 to 3.42), p=0.03), and only LDL-c with IFG (FPG 5.6-<7) (adjusted -0.14 (-0.27, -0.003) p 0.04). There were no significant independent associations with cardiometabolic risk factors when categories of impaired fasting glucose (FPG ≥ 6.1 to <7.0 mmol/L) were considered. Relative to White, South Asian ethnicity was independently associated with lower systolic and diastolic BP, Black with lower triglycerides, cholesterol/HDL-c ratio and having 2 or more IRFs, and Thai with lower cholesterol/HDL-c ratio and all three non-white ethnicities with lower total and LDL cholesterol. CONCLUSION: In high-risk HbA1c-defined prediabetes additional measurement of FPG will add little to evaluation of cardiometabolic risk. Additionally, UK Whites tend to have the most adverse cardiometabolic profile of any ethnic group.
Issue Date: 23-Oct-2017
Date of Acceptance: 18-Oct-2017
URI: http://hdl.handle.net/10044/1/53275
DOI: https://dx.doi.org/10.1016/j.diabres.2017.10.017
ISSN: 0168-8227
Publisher: Elsevier
Start Page: 183
End Page: 190
Journal / Book Title: Diabetes Research and Clinical Practice
Volume: 134
Copyright Statement: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: MR/J000183/1
n/a
Keywords: Cardiometabolic risk factor
Ethnicity
Fasting plasma glucose
HbA1c
Impaired fasting glucose
Prediabetes
cardiometabolic risk factor
ethnicity
fasting plasma glucose
impaired fasting glucose
prediabetes
1103 Clinical Sciences
Endocrinology & Metabolism
Publication Status: Published online
Appears in Collections:Department of Medicine
Faculty of Medicine



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