Probing T-1-T-2 interactions and their imaging implications through a thermally responsive nanoprobe

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Title: Probing T-1-T-2 interactions and their imaging implications through a thermally responsive nanoprobe
Authors: Gallo, J
Harriss, BI
Hernandez-Gil, J
Banobre-Lopez, M
Long, NJ
Item Type: Journal Article
Abstract: The complex and specialised diagnostic process through magnetic resonance imaging (MRI) could be simplified with the implementation of dual T1–T2 contrast agents. T1- and T2-weighted MR are compatible modalities, and co-acquisition of contrast enhanced images in both T1 and T2 will drastically reduce artefacts and provide double-checked results. To date, efforts in the development of dual MRI probes have provided inconsistent results. Here we present the preparation and relaxometric study of a dual T1–T2 MRI probe based on superparamagnetic nanoparticles, paramagnetic Gd3+ chelates and pNIPAM (poly(N-isopropylacrylamide)), in which the distance between paramagnetic and superparamagnetic species can be modulated externally via temperature variations. Such a probe alleviates traditional nanotechnology limitations (e.g. batch to batch variability) as comparisons can be established within a single probe.
Issue Date: 1-Aug-2017
Date of Acceptance: 30-Jun-2017
URI: http://hdl.handle.net/10044/1/53270
DOI: https://dx.doi.org/10.1039/c7nr01733b
ISSN: 2040-3364
Publisher: Royal Society of Chemistry
Start Page: 11318
End Page: 11326
Journal / Book Title: Nanoscale
Volume: 9
Issue: 31
Copyright Statement: © The Royal Society of Chemistry 2017
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
IRON-OXIDE NANOPARTICLES
MRI CONTRAST AGENT
MAGNETITE NANOPARTICLES
SPIN RELAXATION
T-1
DIFFUSION
POLYMERS
LIQUIDS
SYSTEM
CANCER
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
IRON-OXIDE NANOPARTICLES
MRI CONTRAST AGENT
MAGNETITE NANOPARTICLES
SPIN RELAXATION
T-1
DIFFUSION
POLYMERS
LIQUIDS
SYSTEM
CANCER
10 Technology
02 Physical Sciences
03 Chemical Sciences
Nanoscience & Nanotechnology
Publication Status: Published
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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