Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.

Title: Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.
Authors: Li, H
Harriss, BI
Phinikaridou, A
Lacerda, S
Ramniceanu, G
Doan, B-T
Ho, K-L
Chan, C-F
Lo, W-S
Botnar, RM
Lan, R
Richard, C
Law, G-L
Long, NJ
Wong, K-L
Item Type: Journal Article
Abstract: A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM(-1)s(-1) at 3T, 25 (o)C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.
Issue Date: 8-May-2017
Date of Acceptance: 11-Apr-2017
URI: http://hdl.handle.net/10044/1/53267
DOI: https://dx.doi.org/10.7150/ntno.18619
ISSN: 2206-7418
Publisher: Ivyspring International Publisher
Start Page: 186
End Page: 195
Journal / Book Title: Nanotheranostics
Volume: 1
Issue: 2
Copyright Statement: This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Sponsor/Funder: The Royal Society
Funder's Grant Number: 2013/R3
Keywords: MRI
cisplatin.
drug delivery
fluorescence imaging
multi-modal
prodrug
Publication Status: Published online
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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