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Delivering precision antimicrobial therapy through closed-loop control systems

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Title: Delivering precision antimicrobial therapy through closed-loop control systems
Authors: Rawson, T
O'hare, D
Herrero, P
Sharma, S
Moore, L
De Barra, E
Roberts, J
Gordon, A
Hope, W
Georgiou, P
Cass, A
Holmes, A
Item Type: Journal Article
Abstract: Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.
Issue Date: 1-Apr-2018
Date of Acceptance: 6-Nov-2017
URI: http://hdl.handle.net/10044/1/53229
DOI: https://dx.doi.org/10.1093/jac/dkx458
ISSN: 0305-7453
Publisher: Oxford University Press (OUP)
Start Page: 835
End Page: 843
Journal / Book Title: Journal of Antimicrobial Chemotherapy
Volume: 73
Issue: 4
Sponsor/Funder: National Institute for Health Research
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
National Institute for Health Research
National Institute for Health Research
National Institute for Health Research
National Institute for Health Research
National Institute for Health Research
Institut Merieux
Funder's Grant Number: NIHR/CS/009/007
NIHR Fellowship
RDA02 79560
HPRU-2012-10047
HPRU-2012-10047
II-LA-0313-20004
II-LA-0214-20008
II-LA-0214-20008
RDA02
N/A
Conference Name: ┬ęThe Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Microbiology
Pharmacology & Pharmacy
CRITICALLY-ILL PATIENTS
TRANSDERMAL DRUG-DELIVERY
BETA-LACTAM ANTIBIOTICS
FIELD-EFFECT TRANSISTORS
GLASSY-CARBON ELECTRODE
FLOW-INJECTION ANALYSIS
POPULATION PHARMACOKINETICS
ELECTROCHEMICAL DETECTION
GRAPHENE OXIDE
AMINOGLYCOSIDE ANTIBIOTICS
1115 Pharmacology And Pharmaceutical Sciences
0605 Microbiology
1108 Medical Microbiology
Publication Status: Published
Open Access location: https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkx458/4688914
Online Publication Date: 2017-12-04
Appears in Collections:Faculty of Engineering
Bioengineering
Division of Surgery
Chemistry
Biological and Biophysical Chemistry
Electrical and Electronic Engineering
Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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