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A comparison of neuroimaging abnormalities in multiple sclerosis, major depression and chronic fatigue syndrome (Myalgic Encephalomyelitis): is there a common cause?

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Title: A comparison of neuroimaging abnormalities in multiple sclerosis, major depression and chronic fatigue syndrome (Myalgic Encephalomyelitis): is there a common cause?
Authors: Morris, G
Berk, M
Puri, BK
Item Type: Journal Article
Abstract: There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes. Regional differences in neuronal resistance to oxidative and inflammatory insults and in the performance of antioxidant defences in the central nervous system may also play a role. Importantly, replicated experimental findings suggest that the use of high-resolution SPECT imaging may have the capacity to differentiate patients afforded a diagnosis of CFS from those with a diagnosis of depression. Further research involving this form of neuroimaging appears warranted in an attempt to overcome the problem of aetiologically heterogeneous cohorts which probably explain conflicting findings produced by investigative teams active in this field. However, the ionising radiation and relative lack of sensitivity involved probably preclude its use as a routine diagnostic tool.
Issue Date: 17-May-2017
Date of Acceptance: 3-May-2017
URI: http://hdl.handle.net/10044/1/53217
DOI: https://dx.doi.org/10.1007/s12035-017-0598-z
ISSN: 0893-7648
Publisher: Springer
Start Page: 3592
End Page: 3609
Journal / Book Title: Molecular Neurobiology
Volume: 55
Issue: 4
Copyright Statement: © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Chronic fatigue syndrome
Depression
Inflammation
Multiple sclerosis
Neuroimaging
1109 Neurosciences
1702 Cognitive Science
Neurology & Neurosurgery
Publication Status: Published
Open Access location: http://link.springer.com/article/10.1007/s12035-017-0598-z
Appears in Collections:Department of Medicine
Faculty of Medicine



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