Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension

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Title: Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension
Author(s): Suzuki, HS
Gao, HG
Bai, WB
Evangelou, EE
Glocker, BG
O'regan, DO
Elliott, PE
Matthews, PMM
Item Type: Journal Article
Abstract: Objectives To characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known neurological or psychiatric disease (62.3±7.4 yrs, 47.0% male) in UK Biobank. Methods For assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p<0.05 after Bonferroni correction). Results The brain white matter intracellular volume fraction was significantly lower, and isotropic volume fraction was higher in hypertensive relative to non-hypertensive individuals (N = 1559, each). The white matter isotropic volume fraction also was higher in pre-hypertensive than in normotensive individuals (N = 694, each) in the right superior longitudinal fasciculus and the right superior thalamic radiation, where the lower intracellular volume fraction was observed in the hypertensives relative to the non-hypertensive group. Significance Pathological processes associated with chronically elevated blood pressure are associated with imaging differences suggesting chronic alterations of white matter axonal structure that may affect cognitive functions even with pre-hypertension.
Publication Date: 16-Nov-2017
Date of Acceptance: 24-Oct-2017
URI: http://hdl.handle.net/10044/1/53181
DOI: https://dx.doi.org/10.1371/journal.pone.0187600
ISSN: 1932-6203
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS ONE
Volume: 12
Issue: 11
Copyright Statement: © 2017 Suzuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
National Institute for Health Research
Public Health England
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: MR/L01632X/1
Keywords: MD Multidisciplinary
General Science & Technology
Publication Status: Published
Article Number: e0187600
Appears in Collections:Faculty of Engineering
Clinical Sciences
Imaging Sciences
Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care

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