Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)

Title: Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
Author(s): Pedersen, M
Mendez, MA
Schoket, B
Godschalk, RW
Espinosa, A
Landstrom, A
Villanueva, CM
Merlo, DF
Fthenou, E
Gracia-Lavedan, E
Van Schooten, F-J
Hoek, G
Brunborg, G
Meltzer, HM
Alexander, J
Nielsen, JK
Sunyer, J
Wright, J
Kovacs, K
De Hoogh, K
Gutzkow, KB
Hardie, LJ
Chatzi, L
Knudsen, LE
Anna, L
Ketzel, M
Haugen, M
Botsivali, M
Nieuwenhuijsen, MJ
Cirach, M
Toledano, MB
Smith, RB
Fleming, S
Agramunt, S
Kyrtopoulos, SA
Lukacs, V
Kleinjans, JC
Segerback, D
Kogevinas, M
Item Type: Journal Article
Abstract: B ackground : Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. o Bjective : We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. M ethods : Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006–2010. Cord blood bulky DNA adduct levels were measured by the 32 P-postlabeling technique ( n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. r esults : Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 ( n = 179) vs. 6.8 ( n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. c onclusion : These findings suggest that a combination of factors, including unknown country- specific factors, influence the bulky DNA adduct levels in neonates. c itation : Pedersen M, Mendez MA, Schoket B, Godschalk RW, Espinosa A, Landström A, Villanueva CM, Merlo DF, Fthenou E, Gracia-Lavedan E, van Schooten FJ, Hoek G, Brunborg G, Meltzer HM, Alexander J, Nielsen JK, Sunyer J, Wright J, Kovács K, de Hoogh K, Gutzkow KB, Hardie LJ, Chatzi L, Knudsen LE, Anna L, Ketzel M, Haugen M, Botsivali M, Nieuwenhuijsen MJ, Cirach M, Toledano MB, Smith RB, Fleming S, Agramunt S, Kyrtopoulos SA, Lukács V, Kleinjans JC, Segerbäck D, Kogevinas M. 2015. Environmental, dietary, maternal, and fetal predic- tors of bulky DNA adducts in cord blood: a European mother–child study
Publication Date: 1-Apr-2015
Date of Acceptance: 23-Jan-2015
URI: http://hdl.handle.net/10044/1/53119
DOI: https://dx.doi.org/10.1289/ehp.1408613
ISSN: 0091-6765
Publisher: The National Institute of Environmental Health Sciences (NIEHS)
Start Page: 374
End Page: 380
Journal / Book Title: Environmental Health Perspectives
Volume: 123
Issue: 4
Sponsor/Funder: Commission of the European Communities
Natural Environment Research Council (NERC)
Funder's Grant Number: FOOD-CT-2006-036224
NE/E008844/1
Copyright Statement: Reproduced with permission from Environmental Health Perspectives. Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Public, Environmental & Occupational Health
Toxicology
Environmental Sciences & Ecology
POLYCYCLIC AROMATIC-HYDROCARBONS
AIR-POLLUTION
BIRTH-WEIGHT
OXIDATIVE STRESS
POOLED ANALYSIS
HUMAN EXPOSURE
HUMAN PLACENTA
TOBACCO-SMOKE
PREGNANCY
WATER
Adult
Air Pollutants
Cohort Studies
DNA Adducts
Diet
Drinking Water
Europe
Female
Fetal Blood
Humans
Infant, Newborn
Male
Maternal Exposure
Maternal-Fetal Exchange
Nitrogen Dioxide
Particulate Matter
Pregnancy
Prenatal Exposure Delayed Effects
Trihalomethanes
Fetal Blood
Humans
Prenatal Exposure Delayed Effects
Nitrogen Dioxide
Trihalomethanes
DNA Adducts
Air Pollutants
Diet
Cohort Studies
Maternal Exposure
Pregnancy
Maternal-Fetal Exchange
Adult
Infant, Newborn
Europe
Female
Male
Particulate Matter
Drinking Water
Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Public, Environmental & Occupational Health
Toxicology
Environmental Sciences & Ecology
POLYCYCLIC AROMATIC-HYDROCARBONS
AIR-POLLUTION
BIRTH-WEIGHT
OXIDATIVE STRESS
POOLED ANALYSIS
HUMAN EXPOSURE
HUMAN PLACENTA
TOBACCO-SMOKE
PREGNANCY
WATER
11 Medical And Health Sciences
05 Environmental Sciences
Toxicology
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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