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Adipokines and inflammation markers and risk of differentiated thyroid carcinoma:the EPIC study

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Title: Adipokines and inflammation markers and risk of differentiated thyroid carcinoma:the EPIC study
Authors: Dossus, L
Franceschi, S
Biessy, C
Navionis, A-S
Travis, R
Weiderpass, E
Scalbert, A
Romieu, I
Tjonneland, A
Olsen, A
Overvad, K
Boutron-Ruault, M-C
Bonnet, F
Fournier, A
Fortner, R
Kaaks, R
Aleksandrova, K
Trichopoulou, A
La Vecchia, C
Peppa, E
Tumino, R
Panico, S
Palli, D
Agnoli, C
Vineis, P
Bueno-de-Mesquita, B
Peeters, PH
Skeie, G
Zamora-Ros, R
Chirlaque, M-D
Ardanaz, E
Sanchez, M-J
Quiros, JR
Dorronsoro, M
Sandstrom, M
Nilsson, LM
Schmidt, JA
Khaw, K-T
Tsilidis, K
Aune, D
Riboli, E
Rinaldi, S
Item Type: Journal Article
Abstract: Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49–0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67–2.76, Ptrend = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13–2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80–3.98, Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
Issue Date: 20-Dec-2017
Date of Acceptance: 6-Nov-2017
URI: http://hdl.handle.net/10044/1/53106
DOI: https://dx.doi.org/10.1002/ijc.31172
ISSN: 0020-7136
Publisher: Wiley
Start Page: 1332
End Page: 1342
Journal / Book Title: International Journal of Cancer
Volume: 142
Issue: 7
Copyright Statement: © 2017 International Agency for Research on Cancer (IARC/WHO); licensed by UICC This is an open access article distributed under the terms of the Creative Commons Attribution IGO License IARC's preferred IGO license is the non-commercial: https://creativecommons.org/licenses/by-nc/3.0/igo/legalcode which permits non-commercial unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited. In any reproduction of this article there should not be any suggestion that IARC/WHO or the article endorse any specific organization or products. The use of the IARC/WHO logo is not permitted. This notice should be preserved along with the article's URL.
Sponsor/Funder: Institut National du Cancer
Funder's Grant Number: NIL
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
thyroid cancer
inflammation
cytokine
adipokine
prospective cohort
C-REACTIVE PROTEIN
PLASMA ADIPONECTIN CONCENTRATIONS
ENDOMETRIAL CANCER-RISK
ADIPOSE-TISSUE
BREAST-CANCER
CIRCULATING ADIPONECTIN
GENE POLYMORPHISM
POOLED ANALYSIS
INTERLEUKIN-10
BIOMARKERS
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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