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Lessons from metabonomics on the neurobiology of stroke

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Title: Lessons from metabonomics on the neurobiology of stroke
Authors: Qureshi, MI
Vorkas, PA
Coupland, AP
Jenkins, IH
Holmes, E
Davies, AH
Item Type: Journal Article
Abstract: The application of metabonomic science to interrogate stroke permits the study of metabolite entities, small enough to cross the blood-brain barrier, that provide insight into neuronal dysfunction, and may serve as reservoirs of biomarker discovery. This systematic review examines the applicability of metabolic profiling in ischemic stroke research. Six human studies utilizing metabolic profiling to analyze biofluids from ischemic stroke patients have been included, employing 1H-NMR and/or mass spectrometry to analyze plasma, serum, and/or urine in a targeted or untargeted fashion. Three are diagnostic studies, and one investigates prognostic biomarkers of stroke recurrence following transient ischemic attack. Two studies focus on metabolic distinguishers of depression or cognitive impairment following stroke. Identified biomarkers from blood and urine predominantly relate to homocysteine and folate, branched chain amino acid, and lipid metabolism. Statistical models are well fitted and reproducible, with excellent validation outcomes, demonstrating the feasibility of metabolic profiling to study a complex disorder with multicausal pathology, such as stroke.
Issue Date: 24-Oct-2016
Date of Acceptance: 1-Oct-2016
URI: http://hdl.handle.net/10044/1/52758
DOI: https://dx.doi.org/10.1177/1073858416673327
ISSN: 1073-8584
Publisher: SAGE Publications
Start Page: 374
End Page: 382
Journal / Book Title: Neuroscientist
Volume: 23
Issue: 4
Copyright Statement: © The Author(s) 2016. The final, definitive version of this paper has been published in Neuroscientist by Sage Publications Ltd. All rights reserved. It is available at: http://journals.sagepub.com/doi/10.1177/1073858416673327
Sponsor/Funder: Imperial College Trust
The Circulation Foundation
Rosetrees Trust
Royal College Of Surgeons Of England
Funder's Grant Number: N/A
N/A
A573
N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
stroke
metabonomics
metabolomics
metabolic profiling
biomarker
CEREBRAL-ARTERY OCCLUSION
SERUM METABOLITES
SYSTEMS BIOLOGY
ISCHEMIC-STROKE
BRAIN-INJURY
ACID
BIOMARKERS
DIAGNOSIS
ATHEROSCLEROSIS
CANNABINOIDS
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Neurology & Neurosurgery
Publication Status: Published
Appears in Collections:Division of Surgery
Faculty of Medicine



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