Altmetric

Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC).

File Description SizeFormat 
Lu_Polyphenols and IBD_Feb 6th 2017.docxAccepted version132.39 kBMicrosoft WordView/Open
Lu_Polyphenols IBD_Tables_20170127.docxAccepted version85.23 kBMicrosoft WordView/Open
Title: Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC).
Authors: Lu, Y
Zamora-Ros, R
Chan, S
Cross, AJ
Ward, H
Jakszyn, P
Luben, R
Opstelten, JL
Oldenburg, B
Hallmans, G
Karling, P
Grip, O
Key, T
Bergmann, MM
Boeing, H
Overvad, K
Palli, D
Masala, G
Khaw, K-T
Racine, A
Carbonnel, F
Boutron-Ruault, M-C
Andersen, V
Olsen, A
Tjonneland, A
Kaaks, R
Tumino, R
Trichopoulou, A
Scalbert, A
Riboli, E
Hart, AR
Item Type: Journal Article
Abstract: BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC. RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance. CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
Issue Date: 22-Aug-2017
Date of Acceptance: 28-Feb-2017
URI: http://hdl.handle.net/10044/1/52709
DOI: https://dx.doi.org/10.1097/MIB.0000000000001108
ISSN: 1078-0998
Publisher: Lippincott, Williams & Wilkins
Start Page: 2072
End Page: 2082
Journal / Book Title: Inflammatory Bowel Diseases
Volume: 23
Issue: 12
Copyright Statement: © 2017 Crohn’s & Colitis Foundation. This is a non-final version of an article published in final form in Inflammatory Bowel Diseases.
Keywords: 1103 Clinical Sciences
Gastroenterology & Hepatology
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx