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Update in Chronic Obstructive Pulmonary Disease 2016

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Title: Update in Chronic Obstructive Pulmonary Disease 2016
Authors: Allinson, JP
Wedzicha, JA
Item Type: Journal Article
Abstract: Chronic obstructive pulmonary disease (COPD) describes a predominantly smoking-induced small airway and/or emphysematous disease associated with airflow limitation. Considered progressive, irreversible, and responsible for substantial morbidity and mortality worldwide, COPD remains the subject of vigorous study, and advances made during 2016 are already reflected in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 guidelines (1). Researchers continue to explore strategies, pharmacological or otherwise, to improve the lives of those who have developed this condition; and it is hoped, by improving phenotyping of this heterogeneous disease, that we might ultimately deliver personalized medicine. Debate remains over how to identify undiagnosed COPD in individuals who would benefit from intervention, while avoiding overdiagnosis, and these controversies perhaps highlight shortcomings in accepted disease definitions. Not unrelatedly, renewed interest has emerged in explaining why some individuals develop COPD and identifying the formative stages of COPD development.
Issue Date: 15-Aug-2017
Date of Acceptance: 31-May-2017
URI: http://hdl.handle.net/10044/1/52613
DOI: https://dx.doi.org/10.1164/rccm.201703-0588UP
ISSN: 1073-449X
Publisher: American Thoracic Society
Start Page: 414
End Page: 424
Journal / Book Title: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume: 196
Issue: 4
Copyright Statement: © 2017 American Thoracic Society
Keywords: Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
RANDOMIZED CONTROLLED-TRIAL
CHRONIC MUCUS HYPERSECRETION
PERIPHERAL ARTERY-DISEASE
ISCHEMIC-HEART-DISEASE
BLOOD EOSINOPHIL COUNT
ASTHMA-LIKE FEATURES
SMALL AIRWAY DISEASE
LONG-TERM OXYGEN
LUNG-FUNCTION
INHALED CORTICOSTEROIDS
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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